Genome Biology

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A Drosophila protein-interaction map centered on cell-cycle regulators

Clement A Stanyon, Guozhen Liu, Bernardo A Mangiola, Nishi Patel, Loic Giot, Bing Kuang, Huamei Zhang, Jinhui Zhong and Russell L Finley*

Genome Biology 2004, 5:R96 doi:10.1186/gb-2004-5-12-r96

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Evolution of biological interaction networks: from models to real data

Mark GF Sun, Philip M Kim Genome Biology 2011, 12:235 (28 December 2011)

Sun and Kim review progress in the study of biological network evolution, with a focus on the protein-protein interaction network

Research   Open Access Highly Accessed

Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function

James C Costello, Mehmet M Dalkilic, Scott M Beason, Jeff R Gehlhausen, Rupali Patwardhan, Sumit Middha, Brian D Eads, Justen R Andrews Genome Biology 2009, 10:R97 (16 September 2009)

The first computational interaction network built from Drosophila melanogaster protein-protein and genetic interaction data allows the functional annotation of orphan genes and reveals clusters of functionally-related genes.

Research article   Open Access

Ontogeny and phylogeny: molecular signatures of selection, constraint, and temporal pleiotropy in the development of Drosophila

Carlo G Artieri, Wilfried Haerty, Rama S Singh BMC Biology 2009, 7:42 (21 July 2009)

Von Baer and Darwin's developmental constraint hypotheses gain support from comparing fruit fly genes across six species, as early-expressed genes are constrained and have more interactions, and adult male gonad genes diverge the most, under positive selection.

Database   Open Access

DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions

Jingkai Yu, Svetlana Pacifico, Guozhen Liu, Russell L Finley BMC Genomics 2008, 9:461 (7 October 2008)

Research article   Open Access

Defining a Modular Signalling Network from the Fly Interactome

Anaïs Baudot, Jean-Baptiste Angelelli, Alain Guénoche, Bernard Jacq, Christine Brun BMC Systems Biology 2008, 2:45 (19 May 2008)

Research   Open Access Highly Accessed

A proteome-wide protein interaction map for Campylobacter jejuni

Jodi R Parrish, Jingkai Yu, Guozhen Liu, Julie A Hines, Jason E Chan, Bernie A Mangiola, Huamei Zhang, Svetlana Pacifico, Farshad Fotouhi, Victor J DiRita, Trey Ideker, Phillip Andrews, Russell L Finley Genome Biology 2007, 8:R130 (5 July 2007)

'Systematic identification of protein interactions for the bacterium Campylobacter jejuni using high-throughput yeast two-hybrid screens detected interactions for 80% of the organism's proteins.

Software   Open Access

FlyMine: an integrated database for Drosophila and Anopheles genomics

Rachel Lyne, Richard Smith, Kim Rutherford, Matthew Wakeling, Andrew Varley, Francois Guillier, Hilde Janssens, Wenyan Ji, Peter Mclaren, Philip North, Debashis Rana, Tom Riley, Julie Sullivan, Xavier Watkins, Mark Woodbridge, Kathryn Lilley, Steve Russell, Michael Ashburner, Kenji Mizuguchi, Gos Micklem Genome Biology 2007, 8:R129 (5 July 2007)

This novel web-based database provides unique accessibility and querying of integrated genomic and proteomic data for Drosophila and Anopheles.

Methodology article   Open Access Highly Accessed

Reconstruction of human protein interolog network using evolutionary conserved network

Tao-Wei Huang, Chung-Yen Lin, Cheng-Yan Kao BMC Bioinformatics 2007, 8:152 (10 May 2007)

Proceedings   Open Access

Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology

Chung-Yen Lin, Shu-Hwa Chen, Chi-Shiang Cho, Chia-Ling Chen, Fan-Kai Lin, Chieh-Hua Lin, Pao-Yang Chen, Chen-Zen Lo, Chao A Hsiung BMC Bioinformatics 2006, 7(Suppl 5):S18 (18 December 2006)

Research article   Open Access Highly Accessed

QPath: a method for querying pathways in a protein-protein interaction network

Tomer Shlomi, Daniel Segal, Eytan Ruppin, Roded Sharan BMC Bioinformatics 2006, 7:199 (10 April 2006)

Database   Open Access

A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila

Svetlana Pacifico, Guozhen Liu, Stephen Guest, Jodi R Parrish, Farshad Fotouhi, Russell L Finley BMC Bioinformatics 2006, 7:195 (7 April 2006)

Software   Open Access

Ulysses - an application for the projection of molecular interactions across species

Danielle Kemmer, Yong Huang, Sohrab P Shah, Jonathan Lim, Jochen Brumm, Macaire MS Yuen, John Ling, Tao Xu, Wyeth W Wasserman, BF Francis Ouellette Genome Biology 2005, 6:R106 (2 December 2005)

Ulysses, a new software for the parallel analysis and display of protein interactions detected in various species, is described.