Table 1

Comparison of Drosophila protein-interaction maps generated by high-throughput yeast two-hybrid methods

LexA cell-cycle map*

Gal4 proteome-wide map

Common


Interactions

1,814

20,439

28

Proteins

488

6,951

347

Proteins as BD fusions

106

3,616

46

Proteins as AD fusions

403

5,425

250

Proteins as AD and BD

21

2,090

8

Degree exponent

1.72

1.91

NA

Mean path length§

3.3

4.1

NA


*The LexA interactions are from this study, listed in Additional data file 3. The Gal4 interactions are from Giot et al. [6]. The chance of observing more than two common interactions between the Gal4 map and a random network with the same topological properties as the LexA map is < 10-6 (see Materials and methods). The degree exponent and mean path length are topological properties of the networks. The degree exponent is γ in the equation P(k) = k, where k is the degree or number of interactions per protein, and P(k) is the distribution of proteins with k interactions. §The mean path length is the shortest number of links between a pair of proteins, averaged over all pairs in the network.

Stanyon et al. Genome Biology 2004 5:R96   doi:10.1186/gb-2004-5-12-r96

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