Table 1

Comparison of Drosophila protein-interaction maps generated by high-throughput yeast two-hybrid methods

LexA cell-cycle map*

Gal4 proteome-wide map^†

Common

Interactions

1,814

20,439

28

Proteins

488

6,951

347

Proteins as BD fusions

106

3,616

46

Proteins as AD fusions

403

5,425

250

Proteins as AD and BD

21

2,090

8

Degree exponent^‡

1.72

1.91

NA

Mean path length^§

3.3

4.1

NA

*The LexA interactions are from this study, listed in Additional data file 3. ^†The Gal4 interactions are from Giot et al. [6]. The chance of observing more than two common interactions between the Gal4 map and a random network with the same topological properties as the LexA map is < 10^-6 (see Materials and methods). ^‡The degree exponent and mean path length are topological properties of the networks. The degree exponent is γ in the equation P(k) = k^-γ, where k is the degree or number of interactions per protein, and P(k) is the distribution of proteins with k interactions. ^§The mean path length is the shortest number of links between a pair of proteins, averaged over all pairs in the network.

Stanyon et al. Genome Biology 2004 5:R96   doi:10.1186/gb-2004-5-12-r96