Table 4

Domain pair enrichment

AD domain

BD domain

Domain pairings




Name

Exp

Rand

Fold

P

Name

Exp

Rand

Fold

P

Exp

Rand

Fold

P


Cyclin

8

0.5

16

<0.00002

Protein kinase

30

1.7

18

<0.00002

38

0.6

60

<0.00002

F-box

17

1.2

15

<0.00002

Skp1

4

0.1

75

<0.00002

34

0.3

123

<0.00002

F-box

17

1.2

15

<0.00002

Skp1_POZ

4

0.1

65

<0.00002

34

0.3

123

<0.00002

Homeobox

9

2.9

3

0.00080

Protein kinase

30

1.7

18

<0.00002

33

3.7

9

0.00002

Extensin_2

20

11.0

2

0.00316

Protein kinase

30

1.7

18

<0.00002

33

14.0

2

0.01536

Cyclin_C

4

0.3

15

<0.00002

Protein kinase

30

1.7

18

<0.00002

26

0.3

76

<0.00002

Drf_FH1

11

4.3

3

0.00128

Protein kinase

30

1.7

18

<0.00002

19

5.5

3

0.01278

Cyclin

8

0.5

16

<0.00002

RIO1

11

0.3

39

<0.00002

19

0.3

59

<0.00002

Rrm

12

4.3

3

0.00032

Protein kinase

30

1.7

18

<0.00002

18

5.5

3

0.01692


The top 10 domain pairs observed in the interaction list are shown. As expected from interaction profiles (see text), cyclin and protein kinase domains are significantly associated, as are F-box and Skp domains. RIO1 is a recently described kinase domain [62] while the Extensin_2 domain is a proline-rich sequence. Drf_FH1 is the Diaphanous-related formin domain, a low-complexity 12-residue repeat found in proteins involved with cytoskeletal dynamics and the Rho-family GTPases [63], and the Rrm is an RNA-recognition motif. There are also additional associations between protein kinase domains and nucleic acid metabolism domains (see Additional data file 5). These data demonstrate the capacity of relatively small sets of proteins to generate high-confidence domain associations. A complete list of all domains and domain pairs found in the interaction data is in Additional data file 5.

Stanyon et al. Genome Biology 2004 5:R96   doi:10.1186/gb-2004-5-12-r96

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