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Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination

Nicola Zamboni and Uwe Sauer*

Genome Biology 2004, 5:R99 doi:10.1186/gb-2004-5-12-r99

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Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Lars M Blank, Lars Kuepfer, Uwe Sauer Genome Biology 2005, 6:R49 (17 May 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Genome-scale 13C-flux analysis in Saccharomyces cerevisiae revealed that the apparent dispensability of knockout mutants with metabolic function can be explained by gene inactivity under a particular condition, by network redundancy through duplicated genes or by alternative pathways.

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