The diversity of endothelial cells: a challenge for therapeutic angiogenesis
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven Gasthuisberg O&N, Herestraat 49, 3000 Leuven, Belgium
Genome Biology 2004, 5:207 doi:Published: 29 January 2004
Vascular endothelia comprise a diverse population of cells that specialize in response to genetic programs and environmental cues to take on distinct roles in different vessels, tissues, and organs, and in response to pathophysiological stresses. Characterization of endothelial-cell diversity will facilitate the development of novel, highly specific and safe therapies for many diseases.