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Spreading silence with Sid

Peter van Roessel1,2 and Andrea H Brand1 email

1The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

2Current address: Stanford University School of Medicine, Stanford, CA 94305, USA

author email corresponding author email

Genome Biology 2004, 5:208

Published: 30 January 2004

Subject areas: Genetics, Genome studies, Model organisms, Methods

Abstract

RNA interference (RNAi) has been shown to spread from cell to cell in plants and in Caenorhabditis elegans, but it does not spread in other organisms, such as Drosophila. A recent report demonstrates that a membrane channel, encoded by the gene sid-1, is responsible for the spreading of RNAi between cells.


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