As a service to the research community, Genome Biology used to publish non-peer-reviewed articles in a 'preprint' depository to which any research can be submitted and which all individuals can access free of charge.From January 2006 Genome Biology no longer publishes new articles in this section. Any article could be submitted by authors, who have sole responsibility for the article's content. The only screening process is to ensure relevance of the preprint to Genome Biology's scope and to avoid abusive, libellous or indecent articles. Articles in this section of the journal have not been peer-reviewed. Each preprint has a permanent URL, by which it can be cited. Research submitted to the preprint depository may be simultaneously or subsequently submitted to Genome Biology or any other publication for peer review; the only requirement is an explicit citation of, and link to, the preprint in the article that is eventually published. If possible, Genome Biology will provide a reciprocal link from the preprint depository to the published article.

Deposited research article

Prediction for Target Sites of Small Interfering RNA Duplexes in SARS Coronavirus

Fengmin Ji¹ and Liaofu Luo^2,3

¹Institute for Biological Science and Technology,Faculty of Sciences, North Jiaotong University, Beijing, 100044 China

²Laboratory of Theoretical Biophysics, Faculty of Sciences and Technology, Inner Mongolia University, Hohhot, 010021 China

³Center for Theoretical Biology, Peking University, Beijing, 100871 China

author email corresponding author email

Genome Biology 2004, 5:P6doi:10.1186/gb-2004-5-2-p6

Published:	16 January 2004

This is the first version of this article to be made available publicly.

Subject areas: Virology, Bioinformatics, Molecular biology, Genome studies

Abstract

RNA interference is used for SARS-related pharmaceutical research and development. Following bioinformatic method twenty seven 21~25 base-long sequence segments in SARS-CoV genome are predicted as the optimal target sites of small interfering RNA duplexes.