Figure 3.

Prediction of strong interactions and non-interactions. Predictions are shown in red for the base-optimized weights, in blue for the coupling-energy weights, and in green for the simple electrostatic weights. (a) The fraction of strong coiled-coil interactions correctly identified as interactions (TP/(TP+FN)) as a function of the number of non-interactions incorrectly identified as interactions (FP). The second y-axis shows the number of strong coiled-coil interactions (TP). (b) The fraction of non-interactions correctly identified (TN/(TN+FP)), as a function of the number of strong interactions incorrectly identified as non-interactions (FN). The second y-axis shows the number of non-interactions (TN).