Genome Biology

official impact factor 6.89

Open Access Highly Access

Versatile and open software for comparing large genomes

Stefan Kurtz, Adam Phillippy, Arthur L Delcher, Michael Smoot, Martin Shumway, Corina Antonescu and Steven L Salzberg*

Genome Biology 2004, 5:R12 doi:10.1186/gb-2004-5-2-r12

Accesses  

  • Last 30 days: 148 accesses
  • Last year: 2230 accesses
  • All time: 18175 accesses

Cited by

BioMed Central: 90 citations

Short Report   Open Access

A cost-effective and universal strategy for complete prokaryotic genomic sequencing proposed by computer simulation

Jingwei Jiang, Jun Li, Hoi Shan Kwan, Chun Hang Au, Patrick Tik Wan Law, Lei Li, Kai Man Kam, Julia Mei Lun Ling, Frederick C Leung BMC Research Notes 2012, 5:80 (31 January 2012)

Research article   Open Access

Comparative genomic analysis of Streptococcus suis reveals significant genomic diversity among different serotypes

Anding Zhang, Ming Yang, Pan Hu, Jiayan Wu, Bo Chen, Yafeng Hua, Jun Yu, Huanchun Chen, Jingfa Xiao, Meilin Jin BMC Genomics 2011, 12:523 (25 October 2011)

Research article   Open Access Highly Accessed

De novo sequence assembly of Albugo candida reveals a small genome relative to other biotrophic oomycetes

Matthew G Links, Eric Holub, Rays HY Jiang, Andrew G Sharpe, Dwayne Hegedus, Elena Beynon, Dean Sillito, Wayne E Clarke, Shihomi Uzuhashi, Mohammad H Borhan BMC Genomics 2011, 12:503 (13 October 2011)

Research article   Open Access

Updated genome assembly and annotation of Paenibacillus larvae, the agent of American foulbrood disease of honey bees

Queenie WT Chan, R Scott Cornman, Inanc Birol, Nancy Y Liao, Simon K Chan, T Roderick Docking, Shaun D Jackman, Greg A Taylor, Steven JM Jones, Dirk C de Graaf, Jay D Evans, Leonard J Foster BMC Genomics 2011, 12:450 (16 September 2011)

Software review   Open Access

SNIT: SNP identification for strain typing

Ravi Vijaya Satya, Nela Zavaljevski, Jaques Reifman Source Code for Biology and Medicine 2011, 6:14 (8 September 2011)

Proceedings   Open Access

Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts

Brian M Forde, B Neville, Michelle M O’ Donnell, E Riboulet-Bisson, M J Claesson, Avril Coghlan, R Ross, Paul W O’ Toole Microbial Cell Factories 2011, 10(Suppl 1):S13 (30 August 2011)

Research article   Open Access Highly Accessed

Genome sequencing reveals diversification of virulence factor content and possible host adaptation in distinct subpopulations of Salmonella enterica

Henk C den Bakker, Andrea I Moreno Switt, Gregory Govoni, Craig A Cummings, Matthew L Ranieri, Lovorka Degoricija, Karin Hoelzer, Lorraine D Rodriguez-Rivera, Stephanie Brown, Elena Bolchacova, Manohar R Furtado, Martin Wiedmann BMC Genomics 2011, 12:425 (22 August 2011)

Software   Open Access Highly Accessed

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

Nabil-Fareed Alikhan, Nicola K Petty, Nouri L Ben Zakour, Scott A Beatson BMC Genomics 2011, 12:402 (8 August 2011)

The BLAST Ring Image Generator (BRIG) software allows users to rapidly visualize comparisons between large numbers of bacterial genomes, including unfinished or unassembled genome data, in a single image.

Research article   Open Access

Complete genome sequence of Brachyspira intermedia reveals unique genomic features in Brachyspira species and phage-mediated horizontal gene transfer

Therese Håfström, Désirée S Jansson , Bo Segerman BMC Genomics 2011, 12:395 (4 August 2011)

Research article   Open Access

Sequencing of a QTL-rich region of the Theobroma cacao genome using pooled BACs and the identification of trait specific candidate genes

Frank A Feltus, Christopher A Saski, Keithanne Mockaitis, Niina Haiminen, Laxmi Parida, Zachary Smith, James Ford, Margaret E Staton, Stephen P Ficklin, Barbara P Blackmon, Chun-Huai Cheng, Raymond J Schnell, David N Kuhn, Juan-Carlos Motamayor BMC Genomics 2011, 12:379 (27 July 2011)

Research   Open Access

Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis

Emily N Barker, Alistair C Darby, Chris R Helps, Iain R Peters, Kate J Heesom, Christopher J Arthur, Ben Crossett, Margaret A Hughes, Alan D Radford, Séverine Tasker Veterinary Research 2011, 42:83 (12 July 2011)

Research article   Open Access Highly Accessed

Identification of lignin genes and regulatory sequences involved in secondary cell wall formation in Acacia auriculiformis and Acacia mangium via de novo transcriptome sequencing

Melissa ML Wong, Charles H Cannon, Ratnam Wickneswari BMC Genomics 2011, 12:342 (5 July 2011)

Software review   Open Access

CONTIGuator: a bacterial genomes finishing tool for structural insights on draft genomes

Marco Galardini, Emanuele G Biondi, Marco Bazzicalupo, Alessio Mengoni Source Code for Biology and Medicine 2011, 6:11 (21 June 2011)

Methodology article   Open Access Highly Accessed

Querying large read collections in main memory: a versatile data structure

Nicolas Philippe, Mikaël Salson, Thierry Lecroq, Martine Léonard, Thérèse Commes, Eric Rivals BMC Bioinformatics 2011, 12:242 (17 June 2011)

Research article   Open Access

Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia

Gvantsa Chanturia, Dawn N Birdsell, Merab Kekelidze, Ekaterine Zhgenti, George Babuadze, Nikoloz Tsertsvadze, Shota Tsanava, Paata Imnadze, Stephen M Beckstrom-Sternberg, James S Beckstrom-Sternberg, Mia D Champion, Shripad Sinari, Miklos Gyuranecz, Jason Farlow, Amanda H Pettus, Emily L Kaufman, Joseph D Busch, Talima Pearson, Jeffrey T Foster, Amy J Vogler, David M Wagner, Paul Keim BMC Microbiology 2011, 11:139 (17 June 2011)

Research   Open Access Highly Accessed

Complete Columbian mammoth mitogenome suggests interbreeding with woolly mammoths

Jacob Enk, Alison Devault, Regis Debruyne, Christine E King, Todd Treangen, Dennis O'Rourke, Steven L Salzberg, Daniel Fisher, Ross MacPhee, Hendrik Poinar Genome Biology 2011, 12:R51 (31 May 2011)

A surprising mtDNA phylogeny suggests that North American woolly mammoths bred with the distinct Columbian mammoth species

Research   Open Access Highly Accessed

A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi

James K Hane, Thierry Rouxel, Barbara J Howlett, Gert HJ Kema, Stephen B Goodwin, Richard P Oliver Genome Biology 2011, 12:R45 (24 May 2011)

Mesosynteny, in which genes are maintained on the same chromosome but in different orders, is revealed in different ascomycete species

Research   Open Access

Linkage disequilibrium based genotype calling from low-coverage shotgun sequencing reads

Jorge Duitama, Justin Kennedy, Sanjiv Dinakar, Yözen Hernández, Yufeng Wu, Ion I Măndoiu BMC Bioinformatics 2011, 12(Suppl 1):S53 (15 February 2011)

Methodology article   Open Access Highly Accessed

A genome alignment algorithm based on compression

Minh Cao, Trevor I Dix, Lloyd Allison BMC Bioinformatics 2010, 11:599 (16 December 2010)

Research article   Open Access Highly Accessed

An algorithm for automated closure during assembly

Sergey Koren, Jason R Miller, Brian P Walenz, Granger Sutton BMC Bioinformatics 2010, 11:457 (10 September 2010)

Research   Open Access

Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates

Bernice Meng Qi Sim, Narisara Chantratita, Wen Fong Ooi, Tannistha Nandi, Ryan Tewhey, Vanaporn Wuthiekanun, Janjira Thaipadungpanit, Sarinna Tumapa, Pramila Ariyaratne, Wing-Kin Sung, Xiao Hui Sem, Hui Hoon Chua, Kalpana Ramnarayanan, Chi Ho Lin, Yichun Liu, Edward J Feil, Mindy B Glass, Gladys Tan, Sharon J Peacock, Patrick Tan Genome Biology 2010, 11:R89 (27 August 2010)

Sequencing and microarray analyses of non-pathogenic and pathogenic Burkholderia isolates reveals insight into the factors underlying the acquisition of pathogenesis.

Research article   Open Access Highly Accessed

A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus

Jörg Barke, Ryan F Seipke, Sabine Grüschow, Darren Heavens, Nizar Drou, Mervyn J Bibb, Rebecca JM Goss, Douglas W Yu, Matthew I Hutchings BMC Biology 2010, 8:109 (26 August 2010)

Leaf-cutter ants cultivate fungi for food, and provide antifungals from associated bacteria to weed out unwanted necrotizing species. Controversy over whether the bacteria are vertically transmitted symbionts or horizontally transmitted environmental species is now resolved: they’re both.

Research article   Open Access

Mobile genetic element proliferation and gene inactivation impact over the genome structure and metabolic capabilities of Sodalis glossinidius, the secondary endosymbiont of tsetse flies

Eugeni Belda, Andrés Moya, Stephen Bentley, Francisco J Silva BMC Genomics 2010, 11:449 (22 July 2010)

Software   Open Access

A high-throughput pipeline for the design of real-time PCR signatures

Ravi Vijaya Satya, Kamal Kumar, Nela Zavaljevski, Jaques Reifman BMC Bioinformatics 2010, 11:340 (23 June 2010)

Research article   Open Access

Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies

Michael D Harwich, Joao M Alves, Gregory A Buck, Jerome F Strauss, Jennifer L Patterson, Aminat T Oki, Philippe H Girerd, Kimberly K Jefferson BMC Genomics 2010, 11:375 (11 June 2010)

Research article   Open Access Highly Accessed

Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8

Max Farnbacher, Thomas Jahns, Dirk Willrodt, Rolf Daniel, Rainer Haas, Alexander Goesmann, Stefan Kurtz, Gabriele Rieder BMC Genomics 2010, 11:335 (27 May 2010)

Research article   Open Access Highly Accessed

Comparative genomic analysis reveals evidence of two novel Vibrio species closely related to V. cholerae

Bradd J Haley, Christopher J Grim, Nur A Hasan, Seon-Young Choi, Jongsik Chun, Thomas S Brettin, David C Bruce, Jean F Challacombe, J Chris Detter, Cliff S Han, Anwar Huq, Rita R Colwell BMC Microbiology 2010, 10:154 (27 May 2010)

Research article   Open Access Highly Accessed

Cgaln: fast and space-efficient whole-genome alignment

Ryuichiro Nakato, Osamu Gotoh BMC Bioinformatics 2010, 11:224 (30 April 2010)

Research   Open Access Highly Accessed

Small variable segments constitute a major type of diversity of bacterial genomes at the species level

Fabrice Touzain, Erick Denamur, Claudine Médigue, Valérie Barbe, Meriem El Karoui, Marie-Agnès Petit Genome Biology 2010, 11:R45 (30 April 2010)

Comparison of all available genomes of three bacterial species suggests that a large part of genome diversity is contributed by short regions.

Research article   Open Access Highly Accessed

Novel insights into the genomic basis of citrus canker based on the genome sequences of two strains of Xanthomonas fuscans subsp. aurantifolii

Leandro M Moreira, Nalvo F Almeida, Neha Potnis, Luciano A Digiampietri, Said S Adi, Julio C Bortolossi, Ana C da Silva, Aline M da Silva, Fabrício E de Moraes, Julio C de Oliveira, Robson F de Souza, Agda P Facincani, André L Ferraz, Maria I Ferro, Luiz R Furlan, Daniele F Gimenez, Jeffrey B Jones, Elliot W Kitajima, Marcelo L Laia, Rui P Leite, Milton Y Nishiyama, Julio Rodrigues Neto, Letícia A Nociti, David J Norman, Eric H Ostroski, Haroldo A Pereira, Brian J Staskawicz, Renata I Tezza, Jesus A Ferro, Boris A Vinatzer, João C Setubal et al. BMC Genomics 2010, 11:238 (13 April 2010)

Method   Open Access

Detection and correction of false segmental duplications caused by genome mis-assembly

David R Kelley, Steven L Salzberg Genome Biology 2010, 11:R28 (10 March 2010)

A method for determining false segmental duplications in vertebrate genomes, thus correcting mis-assemblies and providing more accurate estimates of duplications.

Research article   Open Access Highly Accessed

High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak

Matthew W Gilmour, Morag Graham, Gary Van Domselaar, Shaun Tyler, Heather Kent, Keri M Trout-Yakel, Oscar Larios, Vanessa Allen, Barbara Lee, Celine Nadon BMC Genomics 2010, 11:120 (18 February 2010)

Research   Open Access

Phylogenetic comparative assembly

Peter Husemann, Jens Stoye Algorithms for Molecular Biology 2010, 5:3 (4 January 2010)

This article is part of a collection on Selected papers from WABI...

Research   Open Access Highly Accessed

Genomic characterization of the Yersinia genus

Peter E Chen, Christopher Cook, Andrew C Stewart, Niranjan Nagarajan, Dan D Sommer, Mihai Pop, Brendan Thomason, Maureen Thomason, Shannon Lentz, Nichole Nolan, Shanmuga Sozhamannan, Alexander Sulakvelidze, Alfred Mateczun, Lei Du, Michael E Zwick, Timothy D Read Genome Biology 2010, 11:R1 (4 January 2010)

Comparative Yersinia genomics identifies features responsible for the colonization of specific host habitats and the horizontal transfer of virulence determinants.

Proceedings   Open Access

RExPrimer: an integrated primer designing tool increases PCR effectiveness by avoiding 3' SNP-in-primer and mis-priming from structural variation

Jittima Piriyapongsa, Chumpol Ngamphiw, Anunchai Assawamakin, Pongsakorn Wangkumhang, Payiarat Suwannasri, Uttapong Ruangrit, Gallissara Agavatpanitch, Sissades Tongsima BMC Genomics 2009, 10(Suppl 3):S4 (3 December 2009)

Research article   Open Access

Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer

Talima Pearson, Philip Giffard, Stephen Beckstrom-Sternberg, Raymond Auerbach, Heidie Hornstra, Apichai Tuanyok, Erin P Price, Mindy B Glass, Benjamin Leadem, James S Beckstrom-Sternberg, Gerard J Allan, Jeffrey T Foster, David M Wagner, Richard T Okinaka, Siew Sim, Ofori Pearson, Zaining Wu, Jean Chang, Rajinder Kaul, Alex R Hoffmaster, Thomas S Brettin, Richard A Robison, Mark Mayo, Jay E Gee, Patrick Tan, Bart J Currie, Paul Keim BMC Biology 2009, 7:78 (18 November 2009)

Despite a high level of lateral gene transfer, the phylogeny of Burkholderia pseudomallei is resolved by SNPs in orthologous shared regions, enabling a wider gene-based analysis to define two populations, ancestral Australian, and South East Asian, separated by the Wallace Line.

Research article   Open Access

Characterization of meiotic crossovers and gene conversion by whole-genome sequencing in Saccharomyces cerevisiae

Ji Qi, Asela J Wijeratne, Lynn P Tomsho, Yi Hu, Stephan C Schuster, Hong Ma BMC Genomics 2009, 10:475 (15 October 2009)

Research article   Open Access

Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and F and Clostridium butyricum type E strains

Karen K Hill, Gary Xie, Brian T Foley, Theresa J Smith, Amy C Munk, David Bruce, Leonard A Smith, Thomas S Brettin, John C Detter BMC Biology 2009, 7:66 (5 October 2009)

Botulinum neurotoxin genes in Clostridium strains are found associated with insertion elements and recombinases, and show evidence of many recombination events, supporting the importance of horizontal gene transfer and recombination in pathogen evolution.

Research article   Open Access Highly Accessed

A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528

David J Studholme, Selena Ibanez, Daniel MacLean, Jeffery L Dangl, Jeff H Chang, John P Rathjen BMC Genomics 2009, 10:395 (24 August 2009)

Research article   Open Access Highly Accessed

Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content

Fumito Maruyama, Mitsuhiko Kobata, Ken Kurokawa, Keishin Nishida, Atsuo Sakurai, Kazuhiko Nakano, Ryota Nomura, Shigetada Kawabata, Takashi Ooshima, Kenta Nakai, Masahira Hattori, Shigeyuki Hamada, Ichiro Nakagawa BMC Genomics 2009, 10:358 (5 August 2009)

Research article   Open Access Highly Accessed

Brucella microti: the genome sequence of an emerging pathogen

Stéphane Audic, Magali Lescot, Jean-Michel Claverie, Holger C Scholz BMC Genomics 2009, 10:352 (4 August 2009)

Methodology article   Open Access

A compartmentalized approach to the assembly of physical maps

Serdar Bozdag, Timothy J Close, Stefano Lonardi BMC Bioinformatics 2009, 10:217 (15 July 2009)

Research   Open Access Highly Accessed

A whole-genome assembly of the domestic cow, Bos taurus

Aleksey V Zimin, Arthur L Delcher, Liliana Florea, David R Kelley, Michael C Schatz, Daniela Puiu, Finnian Hanrahan, Geo Pertea, Curtis P Van Tassell, Tad S Sonstegard, Guillaume Marçais, Michael Roberts, Poorani Subramanian, James A Yorke, Steven L Salzberg Genome Biology 2009, 10:R42 (24 April 2009)

A cow whole-genome assembly of 2.86 billion base pairs that closes gaps and corrects previously-described inversions and deletions as well as describing a portion of the Y chromosome.

Methodology article   Open Access Highly Accessed

Development and evaluation of new mask protocols for gene expression profiling in humans and chimpanzees

Donna M Toleno, Gabriel Renaud, Tyra G Wolfsberg, Munirul Islam, Derek E Wildman, Kimberly D Siegmund, Joseph G Hacia BMC Bioinformatics 2009, 10:77 (5 March 2009)

Research   Open Access

Crystallizing short-read assemblies around seeds

Mohammad Hossain, Navid Azimi, Steven Skiena BMC Bioinformatics 2009, 10(Suppl 1):S16 (30 January 2009)

Research article   Open Access Highly Accessed

Genome and gene alterations by insertions and deletions in the evolution of human and chimpanzee chromosome 22

Natalia Volfovsky, Taras K Oleksyk, Kristine C Cruz, Ann L Truelove, Robert M Stephens, Michael W Smith BMC Genomics 2009, 10:51 (26 January 2009)

Research   Open Access Highly Accessed

Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage

Jean-Marc Rolain, Patrice François, David Hernandez, Fadi Bittar, Hervé Richet, Ghislain Fournous, Yves Mattenberger, Emmanuelle Bosdure, Nathalie Stremler, Jean-Christophe Dubus, Jacques Sarles, Martine Reynaud-Gaubert, Stephanie Boniface, Jacques Schrenzel, Didier Raoult Biology Direct 2009, 4:1 (13 January 2009)

Research article   Open Access

Conservation in the face of diversity: multistrain analysis of an intracellular bacterium

Michael J Dark, David R Herndon, Lowell S Kappmeyer, Mikel P Gonzales, Elizabeth Nordeen, Guy H Palmer, Donald P Knowles, Kelly A Brayton BMC Genomics 2009, 10:16 (11 January 2009)

Research article   Open Access

Comparative genomics of vesicomyid clam (Bivalvia: Mollusca) chemosynthetic symbionts

Irene LG Newton, Peter R Girguis, Colleen M Cavanaugh BMC Genomics 2008, 9:585 (4 December 2008)

Research article   Open Access

LTR retrotransposons reveal recent extensive inter-subspecies nonreciprocal recombination in Asian cultivated rice

Hao Wang, Zhao Xu, Hongjie Yu BMC Genomics 2008, 9:565 (27 November 2008)

Database   Open Access

MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level

Hélène Chiapello, Annie Gendrault, Christophe Caron, Jérome Blum, Marie-Agnès Petit, Meriem El Karoui BMC Bioinformatics 2008, 9:498 (27 November 2008)

Methodology article   Open Access

In silico microarray probe design for diagnosis of multiple pathogens

Ravi Vijaya Satya, Nela Zavaljevski, Kamal Kumar, Elizabeth Bode, Susana Padilla, Leonard Wasieloski, Jeanne Geyer, Jaques Reifman BMC Genomics 2008, 9:496 (21 October 2008)

Research article   Open Access

A comparative computational analysis of nonautonomous Helitron elements between maize and rice

Michael Sweredoski, Leah DeRose-Wilson, Brandon S Gaut BMC Genomics 2008, 9:467 (8 October 2008)

Research article   Open Access Highly Accessed

The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen

Michael E Reith, Rama K Singh, Bruce Curtis, Jessica M Boyd, Anne Bouevitch, Jennifer Kimball, Janet Munholland, Colleen Murphy, Darren Sarty, Jason Williams, John HE Nash, Stewart C Johnson, Laura L Brown BMC Genomics 2008, 9:427 (18 September 2008)

The genome sequence of the bacterium Aeromonas salmonicida and the comparison of it to Aeromonas hydrophila yields new insights into the evolution and virulence factors that cause furunculusis, a bacterial septicaemia, in salmonid fish.

Software   Open Access Highly Accessed

GenomeMatcher: A graphical user interface for DNA sequence comparison

Yoshiyuki Ohtsubo, Wakako Ikeda-Ohtsubo, Yuji Nagata, Masataka Tsuda BMC Bioinformatics 2008, 9:376 (16 September 2008)

Methodology article   Open Access

ReRep: Computational detection of repetitive sequences in genome survey sequences (GSS)

Thomas D Otto, Leonardo HF Gomes, Marcelo Alves-Ferreira, Antonio B de Miranda, Wim M Degrave BMC Bioinformatics 2008, 9:366 (9 September 2008)

Research article   Open Access Highly Accessed

Analysis of 90 Mb of the potato genome reveals conservation of gene structures and order with tomato but divergence in repetitive sequence composition

Wei Zhu, Shu Ouyang, Marina Iovene, Kimberly O'Brien, Hue Vuong, Jiming Jiang, C Robin Buell BMC Genomics 2008, 9:286 (13 June 2008)

Methodology   Open Access

Development and evaluation of a high-throughput, low-cost genotyping platform based on oligonucleotide microarrays in rice

Jeremy D Edwards, Jaroslav Janda, Megan T Sweeney, Ambika B Gaikwad, Bin Liu, Hei Leung, David W Galbraith Plant Methods 2008, 4:13 (29 May 2008)

Research article   Open Access Highly Accessed

Chloroplast genome sequencing analysis of Heterosigma akashiwo CCMP452 (West Atlantic) and NIES293 (West Pacific) strains

Rose Cattolico, Michael A Jacobs, Yang Zhou, Jean Chang, Melinda Duplessis, Terry Lybrand, John McKay, Han Ong, Elizabeth Sims, Gabrielle Rocap BMC Genomics 2008, 9:211 (8 May 2008)

Research article   Open Access Highly Accessed

Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A

Steven L Salzberg, Daniel D Sommer, Michael C Schatz, Adam M Phillippy, Pablo D Rabinowicz, Seiji Tsuge, Ayako Furutani, Hirokazu Ochiai, Arthur L Delcher, David Kelley, Ramana Madupu, Daniela Puiu, Diana Radune, Martin Shumway, Cole Trapnell, Gudlur Aparna, Gopaljee Jha, Alok Pandey, Prabhu B Patil, Hiromichi Ishihara, Damien F Meyer, Boris Szurek, Valerie Verdier, Ralf Koebnik, J Maxwell Dow, Robert P Ryan, Hisae Hirata, Shinji Tsuyumu, Sang Won Lee, Pamela C Ronald, Ramesh V Sonti, Marie-Anne Van Sluys, Jan E Leach, Frank F White, Adam J Bogdanove et al. BMC Genomics 2008, 9:204 (1 May 2008)

Methodology article   Open Access

A high-throughput pipeline for designing microarray-based pathogen diagnostic assays

Ravi Vijaya Satya, Nela Zavaljevski, Kamal Kumar, Jaques Reifman BMC Bioinformatics 2008, 9:185 (10 April 2008)

Research   Open Access

xMAN: extreme MApping of OligoNucleotides

Wei Li, Jason S Carroll, Myles Brown, X Shirley Liu BMC Genomics 2008, 9(Suppl 1):S20 (20 March 2008)

Method   Open Access Highly Accessed

DNA signatures for detecting genetic engineering in bacteria

Jonathan E Allen, Shea N Gardner, Tom R Slezak Genome Biology 2008, 9:R56 (18 March 2008)

New computational tools were used to find a robust set of DNA oligomers that can distinguish artificial vector sequences from all available background viral and bacterial genomes.

Software   Open Access

Genome assembly forensics: finding the elusive mis-assembly

Adam M Phillippy, Michael C Schatz, Mihai Pop Genome Biology 2008, 9:R55 (14 March 2008)

A collection of software tools is combined for the first time in an automated pipeline for detecting large-scale genome assembly errors and for validating genome assemblies.

Methodology article   Open Access Highly Accessed

Multiple organism algorithm for finding ultraconserved elements

Scott Christley, Neil F Lobo, Greg Madey BMC Bioinformatics 2008, 9:15 (11 January 2008)

Software   Open Access Highly Accessed

SeqAn An efficient, generic C++ library for sequence analysis

Andreas Döring, David Weese, Tobias Rausch, Knut Reinert BMC Bioinformatics 2008, 9:11 (9 January 2008)

Software   Open Access Highly Accessed

High-throughput sequence alignment using Graphics Processing Units

Michael C Schatz, Cole Trapnell, Arthur L Delcher, Amitabh Varshney BMC Bioinformatics 2007, 8:474 (10 December 2007)

Research   Open Access Highly Accessed

Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools

Weichun Huang, Joseph R Nevins, Uwe Ohler Genome Biology 2007, 8:R225 (24 October 2007)

Phylogenetic simulation of promoter evolution were used to analyze functional site turnover in regulatory sequences.

Research article   Open Access

Architecture of Burkholderia cepacia complex σ70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability

Aymeric Menard, Paulina de los Santos, Arnault Graindorge, Benoit Cournoyer BMC Genomics 2007, 8:308 (4 September 2007)

Research article   Open Access

Structure and evolution of a proviral locus of Glyptapanteles indiensis bracovirus

Christopher A Desjardins, Dawn E Gundersen-Rindal, Jessica B Hostetler, Luke J Tallon, Roger W Fuester, Michael C Schatz, Monica J Pedroni, Douglas W Fadrosh, Brian J Haas, Bradley S Toms, Dan Chen, Vishvanath Nene BMC Microbiology 2007, 7:61 (26 June 2007)

Research   Open Access

Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains

Laurence Rohmer, Christine Fong, Simone Abmayr, Michael Wasnick, Theodore Larson Freeman, Matthew Radey, Tina Guina, Kerstin Svensson, Hillary S Hayden, Michael Jacobs, Larry A Gallagher, Colin Manoil, Robert K Ernst, Becky Drees, Danielle Buckley, Eric Haugen, Donald Bovee, Yang Zhou, Jean Chang, Ruth Levy, Regina Lim, Will Gillett, Don Guenthener, Allison Kang, Scott A Shaffer, Greg Taylor, Jinzhi Chen, Byron Gallis, David A D'Argenio, Mats Forsman, Maynard V Olson, David R Goodlett, Rajinder Kaul, Samuel I Miller, Mitchell J Brittnacher et al. Genome Biology 2007, 8:R102 (5 June 2007)

.Sequencing of the non-pathogenic Francisella tularensis sub-species novicida U112, and comparison with two pathogenic sub-species, provides insights into the evolution of pathogenicity in these species.

Software   Open Access Highly Accessed

Hawkeye: an interactive visual analytics tool for genome assemblies

Michael C Schatz, Adam M Phillippy, Ben Shneiderman, Steven L Salzberg Genome Biology 2007, 8:R34 (9 March 2007)

Hawkeye is a new, freely available visual analytics tool for genome assemblies, designed to aid in identifying and correcting assembly errors.

Research article   Open Access Highly Accessed

Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates

Susan M Kraemer, Sue A Kyes, Gautam Aggarwal, Amy L Springer, Siri O Nelson, Zoe Christodoulou, Leia M Smith, Wendy Wang, Emily Levin, Christopher I Newbold, Peter J Myler, Joseph D Smith BMC Genomics 2007, 8:45 (7 February 2007)

Research   Open Access

GenomeBlast: a web tool for small genome comparison

Guoqing Lu, Liying Jiang, Resa MK Helikar, Thaine W Rowley, Luwen Zhang, Xianfeng Chen, Etsuko N Moriyama BMC Bioinformatics 2006, 7(Suppl 4):S18 (12 December 2006)

Methodology article   Open Access

Composition-based statistics and translated nucleotide searches: Improving the TBLASTN module of BLAST

E Michael Gertz, Yi-Kuo Yu, Richa Agarwala, Alejandro A Schäffer, Stephen F Altschul BMC Biology 2006, 4:41 (7 December 2006)

The first description is now available of the updated TBLASTN, an implementation of the BLAST search that aligns protein sequences to a translated nucleotide database, revealing the composition-based statistics that give increased accuracy and reliability.

Research article   Open Access Highly Accessed

454 sequencing put to the test using the complex genome of barley

Thomas Wicker, Edith Schlagenhauf, Andreas Graner, Timothy J Close, Beat Keller, Nils Stein BMC Genomics 2006, 7:275 (26 October 2006)

Software   Open Access

inGeno – an integrated genome and ortholog viewer for improved genome to genome comparisons

Chunguang Liang, Thomas Dandekar BMC Bioinformatics 2006, 7:461 (20 October 2006)

Research   Open Access Highly Accessed

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial

Daniel G Lee, Jonathan M Urbach, Gang Wu, Nicole T Liberati, Rhonda L Feinbaum, Sachiko Miyata, Lenard T Diggins, Jianxin He, Maude Saucier, Eric Déziel, Lisa Friedman, Li Li, George Grills, Kate Montgomery, Raju Kucherlapati, Laurence G Rahme, Frederick M Ausubel Genome Biology 2006, 7:R90 (12 October 2006)

Sequencing of a highly virulent strain of Pseudomonas aeruginosa and comparison to a previously sequenced, less pathogenic, strain, together with experimental testing in a C. elegans model, suggests that Pseudomonas virulence is multifactorial and combinatorial.

Software   Open Access

M-GCAT: interactively and efficiently constructing large-scale multiple genome comparison frameworks in closely related species

Todd J Treangen, Xavier Messeguer BMC Bioinformatics 2006, 7:433 (5 October 2006)

Software   Open Access

MICA: desktop software for comprehensive searching of DNA databases

William A Stokes, Benjamin S Glick BMC Bioinformatics 2006, 7:427 (3 October 2006)

Research article   Open Access

Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts

Claudia M Romero, David DeShazer, Tamara Feldblyum, Jacques Ravel, Donald Woods, H Stanley Kim, Yan Yu, Catherine M Ronning, William C Nierman BMC Genomics 2006, 7:228 (5 September 2006)

Research   Open Access

Genome-wide detection and analysis of homologous recombination among sequenced strains of Escherichia coli

Bob Mau, Jeremy D Glasner, Aaron E Darling, Nicole T Perna Genome Biology 2006, 7:R44 (31 May 2006)

Multiple alignment of E. coli and Shigella genomes reveals that intraspecific recombination is more common than previously thought.

Research article   Open Access Highly Accessed

Genomic patterns of pathogen evolution revealed by comparison of Burkholderia pseudomallei, the causative agent of melioidosis, to avirulent Burkholderia thailandensis

Yiting Yu, H Stanley Kim, Hui Chua, Chi Lin, Siew Sim, Daoxun Lin, Alan Derr, Reinhard Engels, David DeShazer, Bruce Birren, William C Nierman, Patrick Tan BMC Microbiology 2006, 6:46 (26 May 2006)

Research article   Open Access

Identification of consensus RNA secondary structures using suffix arrays

Mohammad Anwar, Truong Nguyen, Marcel Turcotte BMC Bioinformatics 2006, 7:244 (5 May 2006)

Methodology article   Open Access Highly Accessed

Chaos game representation for comparison of whole genomes

Jijoy Joseph, Roschen Sasikumar BMC Bioinformatics 2006, 7:243 (5 May 2006)

Research article   Open Access Highly Accessed

Detection of non-coding RNAs on the basis of predicted secondary structure formation free energy change

Andrew V Uzilov, Joshua M Keegan, David H Mathews BMC Bioinformatics 2006, 7:173 (27 March 2006)

Research article   Open Access

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops

H Chiapello, I Bourgait, F Sourivong, G Heuclin, A Gendrault-Jacquemard, M-A Petit, M El Karoui BMC Bioinformatics 2005, 6:171 (12 July 2005)

Research article   Open Access

Complete reannotation of the Arabidopsis genome: methods, tools, protocols and the final release

Brian J Haas, Jennifer R Wortman, Catherine M Ronning, Linda I Hannick, Roger K Smith, Rama Maiti, Agnes P Chan, Chunhui Yu, Maryam Farzad, Dongying Wu, Owen White, Christopher D Town BMC Biology 2005, 3:7 (22 March 2005)

The TIGR group explain how they reannotated the Arabidopsis genome, with several thousand new genes and pseudogenes annotated, 1/3 of the original annotations refined and every protein-coding gene assigned to a Gene Ontology term.

Research   Open Access Highly Accessed

Serendipitous discovery of Wolbachia genomes in multiple Drosophila species

Steven L Salzberg, Julie Hotopp, Arthur L Delcher, Mihai Pop, Douglas R Smith, Michael B Eisen, William C Nelson Genome Biology 2005, 6:R23 (22 February 2005)

By searching the publicly available repository of DNA sequencing trace data, we discovered three new species of the bacterial endosymbiont Wolbachia pipientis in three different species of fruit fly: Drosophila ananassae, D. simulans, and D. mojavensis.

Research   Open Access Highly Accessed

Accelerated evolution associated with genome reduction in a free-living prokaryote

Alexis Dufresne, Laurence Garczarek, Frédéric Partensky Genome Biology 2005, 6:R14 (14 January 2005)

Prochlorococcus sp. are marine bacteria with very small genomes. The mechanisms by which these reduced genomes have evolved appears, however, to be distinct from those that have led to small genome size in intracellular bacteria.