Genome Biology

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An unappreciated role for RNA surveillance

R Tyler Hillman, Richard E Green and Steven E Brenner*

Genome Biology 2004, 5:R8 doi:10.1186/gb-2004-5-2-r8

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BioMed Central: 10 citations

Research article   Open Access Highly Accessed

Genome-wide analysis of chimpanzee genes with premature termination codons

Anna Wetterbom, Ulf Gyllensten, Lucia Cavelier, Tomas F Bergström BMC Genomics 2009, 10:56 (29 January 2009)

Research article   Open Access Highly Accessed

Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene

Inge Seim, Shea L Carter, Adrian C Herington, Lisa K Chopin BMC Molecular Biology 2008, 9:95 (28 October 2008)

Research   Open Access

Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome

Noa Sela, Britta Mersch, Nurit Gal-Mark, Galit Lev-Maor, Agnes Hotz-Wagenblatt, Gil Ast Genome Biology 2007, 8:R127 (27 June 2007)

Analysis of transposed elements in the human and mouse genomes reveals many effects on the transcriptomes, including a higher level of exonization of Alu elements than other elements.

Database   Open Access Highly Accessed

A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of human alternative splicing variants

Pierre de la Grange, Martin Dutertre, Margot Correa, Didier Auboeuf BMC Bioinformatics 2007, 8:180 (4 June 2007)

Hypothesis   Open Access Highly Accessed

The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?

Eugene V Koonin Biology Direct 2006, 1:22 (14 August 2006)

Research   Open Access Highly Accessed

Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases

Alistair RR Forrest, Darrin F Taylor, Mark L Crowe, Alistair M Chalk, Nic J Waddell, Gabriel Kolle, Geoffrey J Faulkner, Rimantas Kodzius, Shintaro Katayama, Christine Wells, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Sean M Grimmond Genome Biology 2006, 7:R5 (26 January 2006)

A systematic study of the transcript variants of all protein kinase- and phosphatase-like loci in mouse shows that at least 75% of them generate alternative transcripts, many of which encode different domain structures.

Research article   Open Access

A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay

Natacha Dreumont, Antonella Maresca, Jean-François Boisclair-Lachance, Anne Bergeron, Robert M Tanguay BMC Molecular Biology 2005, 6:1 (7 January 2005)

Methodology article   Open Access

Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing

Shobhit Gupta, Dorothea Zink, Bernhard Korn, Martin Vingron, Stefan A Haas BMC Genomics 2004, 5:72 (28 September 2004)

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Variation in alternative splicing across human tissues

Gene Yeo, Dirk Holste, Gabriel Kreiman, Christopher B Burge Genome Biology 2004, 5:R74 (13 September 2004)

Analysis of the alternative splicing patterns of genomically aligned ESTs revealed that human brain, testis and liver have unusually high levels of alternative splicing and identified candidate cis-acting factors likely to play important roles in tissue-specific alternative splicing in human cells.

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Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Gabriele Neu-Yilik, Niels H Gehring, Matthias W Hentze, Andreas E Kulozik Genome Biology 2004, 5:218 (30 March 2004)

Two new approaches have identified physiological nonsense-mediated mRNA decay (NMD) substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.