Figure 4.

Published expression levels of calpain-10 isoforms are consistent with NMD prediction. (a) A report from Horikawa and co-workers [43] found eight alternative isoforms of calpain-10, of which four are expressed in low abundance. Our analysis found this exact set of four low-abundance isoforms to contain PTCs. (b) Gene structures of alternative mRNA isoforms of calpain-10 show the patterns of alternative splicing and indicate locations of PTCs. Also shown is the position of UCSNP-43, an intronic polymorphism that has been statistically linked to type II diabetes susceptibility in a variety of populations.