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Highly Accessed Review

Identifying transcriptional targets

Nicola V Taverner, James C Smith and Fiona C Wardle*

Author Affiliations

Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK

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Genome Biology 2004, 5:210  doi:10.1186/gb-2004-5-3-210

Published: 27 February 2004

Abstract

Identifying the targets of transcription factors is important for understanding cellular processes. We review how targets have previously been isolated and outline new technologies that are being developed to identify novel direct targets, including chromatin immunoprecipitation combined with microarray screening and bioinformatic approaches.