Table 1

Genomic organization of the human caveolin genes and properties of their protein products
Human gene
 Chromosomal location
 Exon
 Exon size (bp)
 Intron
 Intron size (kb)
 Residues encoded by exon
 Length of protein (amino acids)
 Percentage similarity (identity) to human Cav-1
 Percentage similarity (identity) to human Cav-2
 Expression patterns
Cav-1
 7q31.1
 1
 30
 1
2
3
 1.47
31.8

 1-10
11-65
66-178
 178
-

 59 (40)


 Ubiquitous; highest levels in adipocytes, endothelia, smooth muscle cells, and Type I pneumocytes











Cav-2
 7q31.1
 1
2a
2b
 150
188
151
 1
2

 0.33
5.76

 1-50
51-112
113-162
 162


 58 (38)


 -


 Co-expressed with Cav-1











Cav-3
 3p25
 1
2
 114
342
 1

 ?

 1-38
39-151
 151

 85 (65)

 60 (39)

 Muscle-specific; primarily in skeletal and cardiac myocytes

Abbreviations: bp, base pairs; kb, kilobases; ?, unknown. Modified from Razani et al. [42].

Williams and Lisanti Genome Biology 2004 5:214