Table 1

Characterization of the 60 C. elegans ABC proteins
Subfamily
 ORF name/CGC name
 Chromosome
 GenBank accession number
 Size (amino acids)
 Predicted topology
 cDNA if known
 RNAi phenotype
A
 Abt
 C24F3.5/ Abt-1
 IV
 CAA18775
 1,429
 (6TM-ABC)2
None


C48B4.4/ Ced-7
 III
 NP_499115
 1,704
 (8TM-ABC)2
 Complete
 None


F12B6.1/ Abt-2
 I
 AAB54153
 1,547
 (6TM-ABC)2
 Partial
 None


F55G11.9/ Abt-3
 IV
 CAB05222
 1,431
 (8/4TM-ABC)2
None


F56F4.6
 I
 AAB54203
 260
 ABC
None


Y39D8C.1/ Abt-4
 V
 AAC69223
 1,802
 (6/8TM-ABC)2
 Partial
 None


Y53C10A.9/ Abt-5
 I
 CAA22142
 1,564
 (6TM-ABC)2
 Partial
 None









B
 Pgp (full molecules)
 C05A9.1/ Pgp-5
 X
 CAA94202
 1,283
 (6TM-ABC)2
 Partial
 None


C34G6.4/ Pgp-2
 I
 AAB52482
 1,265
 (6TM-ABC)2
 Partial
 None


C47A10.1/ Pgp-9
 V
 CAB03973
 1,294
 (6TM-ABC)2
 Partial
 None


C54D1.1/ Pgp-10
 X
 AAC48149
 1,283
 (4TM-ABC)2
 Partial
 None


DH11.3/ Pgp-11
 II
 CAA88940
 1,270
 (6TM-ABC)2
 Partial
 None


F22E10.1/ Pgp-12
 X
 CAA91799
 1,318
 (6TM-ABC)2
 Partial
 None


F22E10.2/ Pgp-13
 X
 CAA91800
 1,291
 (6TM-ABC)2
None


F22E10.3/ Pgp-14
 X
 CAA91801
 1,327
 (6TM-ABC)2
 Partial
 None


F22E10.4/ Pgp-15
 X
 CAA91802
 1,270
 (6TM-ABC)2
None


F42E11.1/ Pgp-4
 X
 CAA91463
 1,266
 (6TM-ABC)2
 Partial
 None


K08E7.9/ Pgp-1
 IV
 CAB01232
 1,321
 (6TM-ABC)2
 Partial
 None


T21E8.1/ Pgp-6
 X
 CAA94220
 1,225
 (6TM-ABC)2
 Partial
 None


T21E8.2/ Pgp-7
 X
 CAA94219
 1,269
 (6TM-ABC)2
None


T21E8.3/ Pgp-8
 X
 CAA94203
 1,243
 (6TM-ABC)2
 Partial
 None


ZK455.7/ Pgp-3
 X
 CAA91467
 1,268
 (6TM-ABC)2
 Partial
 None

Haf (half molecules)
 C30H6.6/ Haf-1
 IV
 CAB02812
 586
 4TM-ABC
 Partial
 None


F43E2.4/ Haf-2
 II
 AAC71121
 761
 8TM-ABC
 Partial
 None


F57A10.3/ Haf-3
 V
 CAB09418
 733
 6TM-ABC
 Partial
 None


W04C9.1/ Haf-4
 I
 AAC68724
 787
 8TM-ABC
 Complete
 Weak embryonic lethality, slow growth


W09D6.6/ Haf-5
 III
 CAB04947
 801
 8TM-ABC
 Complete
 None


Y48G8AL.11/ Haf-6
 I
 AAK29911
 565
 4TM-NBF
 Partial


Y50E8A.16/ Haf-7
 V
 CAB60586
 807
 6TM-ABC
 Partial


Y57G11C.1/ Haf-8
 IV
 CAB16503
 633
 4TM-ABC
None


ZK484.2/ Haf-9
 I
 AAK39394
 815
 8TM-ABC
 Complete
 None









C
 Mrp/Cft
 C18C4.2/ Cft-1
 V
 AAK52175
 1247
 (5/6TM-NBF)2
 Partial
 None


E03G2.2/ Mrp-3
 X
 CAA92148
 1,398
 (6TM-ABC)2
 Partial
 None


F14F4.3/ Mrp-5
 X
 CAB54225
 1,427
 (6TM-ABC)2
 Partial
 Slow growth, Clear


F20B6.3/ Mrp-6
 X
 AAA82317
 1,396
 (6TM-ABC)2
 Partial
 Egg laying defect


F21G4.2/ Mrp-4
 X
 CAB02667
 1,573
 (10/6TM-ABC)2
 Partial
 None


F57C12.4/ Mrp-2
 X
 AAB07022
 1,525
 (10/6TM-ABC)2
 Complete
 None


F57C12.5/ Mrp-1
 X
 AAD31550
 1,528
 (12/6TM-ABC)2
 Complete
 None


Y43F8C.12/ Mrp-7
 V
 CAA21622
 1,119
 (12/2TM-ABC)2
 Partial


Y75B8A.26/ Mrp-8
 X
 CAA22110
 1,144
 (4/6TM-ABC)2
 Partial









D
C44B7.8
 II
 AAA68339
 665
 4TM-ABC
 Partial


C44B7.9
 II
 AAA68340
 661
 4TM-ABC
 Partial
 None


C54G10.3
 V
 CAA99810
 660
 6TM-ABC
 Complete
 None


T02D1.5
 IV
 CAB0590
 734
 6TM-ABC
 Partial
 None


T10H9.5
 V
 AAC19238
 598
 6TM-ABC
 Complete
 None









E
Y39E4B.1
 III
 CAB54424
 610
 ABC-ABC
 Partial
 Embryonic lethality









F
F18E2.2
 V
 CAA99835
 622
 ABC-ABC
 Partial
 None


F42A10.1
 III
 AAA19072
 712
 ABC-ABC
 Partial
 None


T27E9.7/ GCN20-2
 III
 CAB04880
 622
 ABC-ABC
 Complete
 None









G
C05D10.3
 III
 AAA20989
 598
 ABC-4TM
 Partial
 None


C10C6.5
 IV
 CAB05682
 610
 ABC-6TM
 Partial
 None


C16C10.12
 III
 CAA86750
 610
 ABC-4TM
 Partial
 None


F02E11.1
 II
 AAB66050
 658
 ABC-4TM
 Partial
 None


F19B6.4
 IV
 CAA93461
 695
 ABC-6TM
 Partial
 None


T26A5.1
 III
 AAC77504
 608
 ABC-4TM
 Partial
 None


Y42G9A.6
 III
 AAF60554
 684
 ABC-6TM
 Partial
 None


Y47D3A.11
 III
 CAB57891
 547
 ABC-6TM
 Partial
 None


Y49E10.9
 III
 CAB11549
 454
 ABC-4TM
None









H
C56E6.1
 II
 AAA81093
 1,667
 ABC-12TM
Larval arrest


C56E6.5
 II
 AAA81094
 595
 ABC-6TM
 Partial
 None

Subfamily names given are according to the HUGO nomenclature (A-H) [33] as well as the CGC (Caenorhabditis Genetics Centre [61]) gene names for each subfamily. TM, transmembrane domain, where the number preceding it is the predicted number of membrane spanning helices or the number in the amino-terminal/carboxy-terminal TM domains, respectively. ABC, ATP-binding cassette. The existence of known cDNAs, whether complete or partial, is listed according to information in WormBase release WS112 [62]. RNAi phenotypes of genes on chromosome I are given according to [63], those on chromosomes II, IV, V and X are from [64], those of genes on chromosome III are from [65].

Sheps et al. Genome Biology 2004 5:R15  

Open Data