Genome Biology
Volume 5
Issue 4 |
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OpinionThe mammalian transcriptome and the function of non-coding DNA sequencesSvetlana A Shabalina1  and Nikolay A Spiridonov2 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA 2Division of Therapeutic Proteins, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda MD 20892, USA  author email corresponding author email
Genome Biology 2004,
5:105
Subject areas: Genome studies, Molecular biology, Genetics, Model organisms Abstract
For decades, researchers have focused most of their attention on protein-coding genes and proteins. With the completion of the human and mouse genomes and the accumulation of data on the mammalian transcriptome, the focus now shifts to non-coding DNA sequences, RNA-coding genes and their transcripts. Many non-coding transcribed sequences are proving to have important regulatory roles, but the functions of the majority remain mysterious. | 
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