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Review

Structural genomics of membrane proteins

Peter Walian1, Timothy A Cross2 and Bing K Jap1*

Author Affiliations

1 Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA

2 National High Magnetic Field Lab and Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA

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Genome Biology 2004, 5:215  doi:

Published: 15 March 2004

Abstract

Improvements in the fields of membrane-protein molecular biology and biochemistry, technical advances in structural data collection and processing, and the availability of numerous sequenced genomes have paved the way for membrane-protein structural genomics efforts. There has been significant recent progress, but various issues essential for high-throughput membrane-protein structure determination remain to be resolved.