Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife
1 Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
2 Molecular Medicine Partnership Unit, EMBL/University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany
3 EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Genome Biology 2004, 5:218 doi:Published: 30 March 2004
Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.