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Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Gabriele Neu-Yilik12*, Niels H Gehring12, Matthias W Hentze23 and Andreas E Kulozik12

Author affiliations

1 Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany

2 Molecular Medicine Partnership Unit, EMBL/University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany

3 EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Citation and License

Genome Biology 2004, 5:218  doi:

Published: 30 March 2004

Abstract

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.