Figure 2.

Simulation of random chromosomal breakage. We performed simulation studies to determine the significance of the observed association of segmental duplications with breakpoints by randomly reassigning breakpoints to positions within the assayed genomic sequence (see Materials and methods). Not once in 10,000 replicates did the simulated count exceed the observed number of duplication-positive breakpoints.

Bailey et al. Genome Biology 2004 5:R23