Table 1

Duplications and syntenic breakpoints in the human genome compared with mouse

Total analyzed

Duplication-positive counts*

Duplication-positive bases

Number

bp

%^†

Number

%

p-value^‡

bp

%

p-value^‡

Duplicated blocks

1,643

72,151,679

2.6

NA

NA

NA

NA

NA

NA

Break points

461

83,985,399

3.1

122

26.5

< 0.0001

20,030,062

23.8

< 0.0001

Between chromosomes

163

42,496,016

1.5

43

26.4

< 0.0001

7,265,961

17.1

< 0.0001

Different orientations

298

41,489,383

1.5

79

26.5

< 0.0001

12,555,425

30.3

< 0.0001

*A positive breakpoint contained ≥ 10 kb duplicated sequence (continuous sequence).^†Fraction of genome size (2,745,533,264 bp, which excludes highly duplicated pericentromeric and subtelomeric regions).^‡p < 0.0001, simulated value never exceeded observed in 10,000 replicates. NA, not applicable.

Bailey et al. Genome Biology 2004 5:R23