Table 1 |
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Classification and chromosomal locations of human sirtuin genes |
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Orthologs |
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|
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|
Name |
Class |
Chromosomal location |
OMIM ID |
Yeast |
Mouse |
|
|
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|
Sirt1 |
Ia |
10q21.3 |
604479 |
Sir2, Hst1 |
Sir2β |
|
Sirt2 |
Ib |
19q13.2 |
604480 |
Hst2 |
Sir2l2 |
|
Sirt3 |
Ib |
11p15.5 |
604481 |
Hst2 |
Sir2l3 |
|
Sirt4 |
II |
12q24.31 |
604482 |
Sirt4 |
|
|
Sirt5 |
III |
6p23 |
604483 |
Sirt5 |
|
|
Sirt6 |
IVa |
19p13.3 |
606211 |
Sirt6 |
|
|
Sirt7 |
IVb |
17q25.3 |
606212 |
Sirt7 |
|
|
|
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|
Mouse orthologs of human Sirt4-7 have not been characterized but are found in sequence databases. OMIM IDs are from the Online Mendelian Inheritance in Man repository at the National Center for Biotechnology Information (NCBI) [76]. |
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North and Verdin Genome Biology 2004 5:224 doi:10.1186/gb-2004-5-5-224 |
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