Orthologous gene-expression profiling in multi-species models: search for candidate genes
1 Center for Translational Respiratory Medicine, Gene Expression Profiling Core, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Hopkins Bayview Circle, Baltimore, MD 21224, USA
2 Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
3 Center for Translational Respiratory Medicine, Johns Hopkins University, Eastern Ave, Baltimore, MD 21224, USA
4 The Institute for Genomic Research, Medical Center Drive, Rockville, MD 20850, USA
5 Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, Baltimore, MD 21287, USA
Genome Biology 2004, 5:R34 doi:Published: 27 April 2004
Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.