After 'completion': the changing face of human chromosomes 21 and 22
RIKEN Genomic Sciences Center, Human Genome Research Group, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Genome Biology 2004, 5:111 doi:10.1186/gb-2004-5-7-111Published: 30 June 2004
In the four years since the publication of the first two 'complete' human chromosome sequences the type of research being done on each has shifted subtly, reflecting the impact of genomic data on biological science in general. There is now considerably more gene-expression evidence to support predicted genes, and the annotation of functions for previously unknown genes, including those implicated in disease, is gradually improving.