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Review

The uses of genome-wide yeast mutant collections

Bart Scherens1 and Andre Goffeau2*

Author affiliations

1 Institut de Recherches Microbiologiques J.M. Wiame, Campus CERIA, Av. E. Gryson 1, 1070 Bruxelles, Belgium

2 Institut des Sciences de la Vie, Université Catholique de Louvain, Croix du Sud 2-20, 1348 Louvain-la-Neuve, Belgium

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Citation and License

Genome Biology 2004, 5:229  doi:10.1186/gb-2004-5-7-229

Published: 25 June 2004

Abstract

We assess five years of usage of the major genome-wide collections of mutants from Saccharomyces cerevisiae: single deletion mutants, double mutants conferring 'synthetic' lethality and the 'TRIPLES' collection of mutants obtained by random transposon insertion. Over 100 experimental conditions have been tested and more than 5,000 novel phenotypic traits have been assigned to yeast genes using these collections.