Table 1

Screens performed so far on the yeast deletion strain collection and transposon-insertion collection

Condition, treatment or phenotype

Number of genes responding to the treatments*

References


Phenotype screens of the deletion collection

Fitness after growth on minimal medium, high salt, low salt, galactose, sorbitol, pH 8, heat shock, cold shock, or hydrogen peroxide

?

[10]

Growth on non-fermentable carbon substrates

466

[11]

Response to DNA-damaging agents, ionizing radiation, UV radiation, cisplatin, or hydrogen peroxide

>170

[13-16]

Chemical DNA damage (methane sulfonate sensitivity)

103

[17]

Enhanced sporulation proficiency

102

[18,19]

Sporulation defects

261

[18,19]

Post-germination defects

158

[18,19]

Genes essential for sporulation

334

[18,19]

Saline response

About 500

[12]

Suppression of the accumulation of mutations

33

[20]

Non-homologous DNA end-joining

About 30

[21]

Ty1 retrotransposition cycle

101

[22]

Response to the introduction of human Huntingtin or α-synuclein fragments (unfolded protein response)

52/86

[23]

Karmellae assembly

120

[24]

Bipolar bud-site selection

127

[25]

Cell-size distribution

500

[26,27]

Altered cell morphology

?

[28]

Meiotic chromosomal segregation

?

[29]

Vacuolar protein sorting

146

[30]

Host genes affecting replication of a positive-strand RNA virus

100

[31]

Glycogen storage (low, high)

324, 242

[32]

Sensitivity of the deletion collection to drugs or chemicals

Rapamycin

106

[43]

PS-341

?

[38]

Bleomycin (hypersensitivity, resistance)

231, 5

[37,40]

Amoxillin, penicillin, rifampin, vancomycin, (oxy)tetracycline, or gentamicin

23

[42]

Anticancer, antifungal agents, statins, alverine citrate, dyclonine, or nystatin

About 10

[10,41]

K1 killer toxin, hygromycin B, calcofluor or sodium dodecyl sulfate

268

[44]

6-Azauracil

42

[45]

Wortmannin (resistance, sensitivity)

591, 476

[39]

Phenotypes of transposon-insertion libraries

Phenotypes under 20 conditions, expression levels and subcellular localization (TRIPLES database)

?

[55]

High salt

31

[58]

Survival of hypo-osmotic shock and growth at 15°C

10

[58]

Ethanol tolerance and cell-wall modifications

5

[59]

Nitrogen starvation, invasive or filamentous growth and sporulation

About 105

[60]


*The number of open reading frames responding to the relevant screen is reported whenever this information could be deduced from the relevant article; ? indicates that the information could not be deduced.

Scherens and Goffeau Genome Biology 2004 5:229   doi:10.1186/gb-2004-5-7-229