Genome Biology

official impact factor 6.89

Open Access

Systematic quantification of gene interactions by phenotypic array analysis

John L Hartman* and Nicholas P Tippery

Genome Biology 2004, 5:R49 doi:10.1186/gb-2004-5-7-r49

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Research   Open Access

Multi-membership gene regulation in pathway based microarray analysis

Stelios P Pavlidis, Annette M Payne, Stephen M Swift Algorithms for Molecular Biology 2011, 6:22 (22 September 2011)

Minireview   Free

A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus Journal of Biology 2008, 7:8 (7 March 2008)

Method   Open Access

High-throughput analysis of spatio-temporal dynamics in Dictyostelium

Satoshi Sawai, Xiao-Juan Guan, Adam Kuspa, Edward C Cox Genome Biology 2007, 8:R144 (21 July 2007)

A time-lapse based approach is presented that allows a rapid examination of the spatio-temporal dynamics of Dictyostelium cell populations, enabling users to search and retrieve movies on a gene-by-gene and phenotype-by-phenotype basis.

Methodology article   Open Access Highly Accessed

Accurate, precise modeling of cell proliferation kinetics from time-lapse imaging and automated image analysis of agar yeast culture arrays

Najaf A Shah, Richard J Laws, Bradley Wardman, Lue Zhao, John L Hartman BMC Systems Biology 2007, 1:3 (8 January 2007)

Automated image analysis of yeast on agar culture arrays provides accurate data on yeast culture biomass, allowing robust quantitative modeling of yeast cell proliferation.

Method   Open Access Highly Accessed

A strategy for extracting and analyzing large-scale quantitative epistatic interaction data

Sean R Collins, Maya Schuldiner, Nevan J Krogan, Jonathan S Weissman Genome Biology 2006, 7:R63 (21 July 2006)

A new technique for analysis of data from synthetic genetic array and E-MAP technology generates high confidence quantitative epistasis scores.