Table 1

Breast cancer susceptibility syndromes

Syndrome

Gene(s) responsible

Other main tumor types

Familial breast and ovarian cancer syndrome

BRCA1 and BRCA2

Ovary, prostate and pancreas

Li-Fraumeni syndrome

P53

Sarcoma and brain

Cowdens syndrome

PTEN

Thyroid and endometrial

Mismatch repair syndrome

MLH1 and MSH2

Gastrointestinal

Peutz-Jegher syndrome

STK11

Gastrointestinal

Trainer Genome Biology 2004 5:113   doi:10.1186/gb-2004-5-8-113