Genome Biology

official impact factor 6.89

Call for an enzyme genomics initiative

Peter D Karp

Genome Biology 2004, 5:401 doi:10.1186/gb-2004-5-8-401

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BioMed Central: 9 citations

Research article   Open Access

The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions

Ottar Rolfsson, Bernhard Ø Palsson, Ines Thiele BMC Systems Biology 2011, 5:155 (1 October 2011)

Research   Open Access

Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Marina V Omelchenko, Michael Y Galperin, Yuri I Wolf, Eugene V Koonin Biology Direct 2010, 5:31 (30 April 2010)

Almost 10% of the biochemical reactions in the Enzyme Commission nomenclature are catalyzed by two or more enzymes with different structural folds and hence independent evolutionary origins.

Software   Open Access

AnEnPi: identification and annotation of analogous enzymes

Thomas D Otto, Ana Guimarães, Wim M Degrave, Antonio B de Miranda BMC Bioinformatics 2008, 9:544 (17 December 2008)

Research article   Open Access Highly Accessed

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

Valérie de Crécy-Lagard, Basma El Yacoubi, Rocío de la Garza, Alexandre Noiriel, Andrew D Hanson BMC Genomics 2007, 8:245 (23 July 2007)

Research article   Open Access

A survey of orphan enzyme activities

Yannick Pouliot, Peter D Karp BMC Bioinformatics 2007, 8:244 (10 July 2007)

Research article   Open Access

In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae

Rui Alves, Albert Sorribas BMC Systems Biology 2007, 1:10 (31 January 2007)

Research article   Open Access Highly Accessed

High precision multi-genome scale reannotation of enzyme function by EFICAz

Adrian K Arakaki, Weidong Tian, Jeffrey Skolnick BMC Genomics 2006, 7:315 (13 December 2006)

Database   Open Access

ORENZA: a web resource for studying ORphan ENZyme activities

Olivier Lespinet, Bernard Labedan BMC Bioinformatics 2006, 7:436 (6 October 2006)

Method   Open Access Highly Accessed

Predicting genes for orphan metabolic activities using phylogenetic profiles

Lifeng Chen, Dennis Vitkup Genome Biology 2006, 7:R17 (15 February 2006)

A method that combines local structure of a metabolic network with phylogenetic profiles is described and used to assign genes to orphan metabolic activities in yeast and Escherichia coli.