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Open letter

Call for an enzyme genomics initiative

Peter D Karp

Author Affiliations

Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA

Genome Biology 2004, 5:401  doi:10.1186/gb-2004-5-8-401

Published: 30 July 2004

Abstract

I propose an Enzyme Genomics Initiative, the goal of which is to obtain at least one protein sequence for each enzyme that has previously been characterized biochemically. There are 1,437 enzyme activities for which Enzyme Commission (EC) numbers have been assigned but no sequence can be found in public protein-sequence databases.