Figure 4.

Proteins identified in this study, as visualized by the Cytoscape platform. Orthologs of all significantly expressed proteins were identified in the NCBI HomoloGene database [45], and curated interactions among the proteins and their orthologs were added from the public HPRD [39], BIND [41] and PreBIND [40] databases as well as a privately curated 'yeast reference network' [40,42-44]. ICAT ratios are indicated by node colors as indexed with a two-fold threshold. Interactions are colored according to their source database, and ortholog-inferred interactions are drawn as dashed lines.