Figure 7.

Analysis of the partners of NFκB members in resting cells. (a) Modular decomposition of the network of NFκB members and their partners. The network is composed of the NFκB members as defined in Figure 6 and their interactors. In this step, interactions among the interactors are disregarded. Symbols for the proteins are as defined in [21]. Baits are outlined in green. Modular decomposition organizes the interactors into modules. The root is a prime whose structure is shown in the encircled network. Module 1 and module 2, respectively, group the new interactors into activators and inhibitors of NFκB. (b) Further purifications using IKKα, IκB-α, IκB-β and Cot/Tpl2 as baits resolve the interactions between module 1 and module 2 members and suggest a complex composed of ABIN2 and Cot/Tpl2 as a NFκB modulation mechanism alternative to IKKα, IκB-α, IκB-β.