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Opinion

Predicting and validating microRNA targets

Eric C Lai

Author Affiliations

545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3200, USA

Genome Biology 2004, 5:115  doi:10.1186/gb-2004-5-9-115

Published: 31 August 2004

Abstract

Given that microRNAs select their targets by nucleotide base-pairing, it follows that it should be possible to find microRNA targets computationally. There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab.