Chemical genomics in yeast
Departments of Genetics and Biochemistry and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Genome Biology 2004, 5:240 doi:10.1186/gb-2004-5-9-240Published: 27 August 2004
Many drugs have unknown, controversial or multiple mechanisms of action. Four recent 'chemical genomic' studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathway-drug interactions.