Table 1

Transcription factors that tend to associate with nucleosome-depleted promoters

Transcription factor
Pathway
Number of targets
Nucleosome-depleted
Functionally cooperative

Rap1
Biosynthesis
291
35%

Fhl1
Biosynthesis
137
48%

Swi4
Cell cycle
165
36%

Hsf1
Environmental response
114
35%

Gat3
Metabolism
119
31%

Cin5
Environmental response
200
23%

Phd1
Metabolism
138
25%

Dal81
Metabolism
70
34%

Ndd1
Cell cycle
122
26%

Yap6
Environmental response
123
26%

Fkh2
Cell cycle
145
24%

Pdr1
Environmental response
103
27%

Ino4
Metabolism
118
25%

Smp1
Environmental response
99
27%

Yap5
Environmental response
113
26%

Ash1
Development
41
41%


Transcription factors are ranked according to the significance of their association with nucleosome-depleted promoters, as determined by a hypergeometric model. Shown are the 16 top-ranked factors along with relevant physiologic pathway, number of promoters bound [1], and percent of target promoters that are nucleosome-depleted. Factors found previously to be functionally cooperative are indicated [22].

Bernstein et al. Genome Biology 2004 5:R62   doi:10.1186/gb-2004-5-9-r62

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