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The number and accuracy of human protein interactions predicted by different model organism protein-interaction datasets |
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| Data source |
Predicted human interactions |
Interactions sharing GO terms |
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| Number |
% |
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| All |
71,496 |
12,724 |
24.9 |
| Yeast |
55,231 |
10,727 |
26.2 |
| Fly |
12,059 |
1,404 |
19.0 |
| Worm |
4,494 |
753 |
24.4 |
| All core |
11,487 |
3,133 |
38.1 |
| Core yeast |
6,061 |
2,146 |
45.4 |
| Core fly |
2,889 |
488 |
27.8 |
| Core worm |
2,701 |
597 |
32.3 |
| Two species |
288 |
154 |
74.8 |
| Two species (core) |
160 |
95 |
88.0 |
| Two methods |
2,166 |
829 |
60.6 |
| Random pairs |
71,496 |
6,053 |
14.6 |
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The table lists the total number of interactions predicted by each interaction dataset, and the number of these interactions that connect proteins that share at least one GO term (at level 3 or deeper in the GO hierarchy). The percentages are relative to the total number of non-self interactions where both proteins have at least one GO annotation. All, all predicted human protein interactions; Yeast/worm/fly, interactions predicted by the yeast, worm or fly interaction maps; All core, all interactions predicted by the high-confidence subsets of each model organism interaction map (see Materials and methods); Two species, interactions predicted by more than one model organism interaction map; Two species (core), interactions predicted by the high-confidence subset of interactions from more than one model organism; Two methods, interactions predicted by data derived from more than one different interaction assay; Random pairs, the data for a randomly generated interaction network. | |||
Lehner and Fraser Genome Biology 2004 5:R63 doi:10.1186/gb-2004-5-9-r63 |
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