Table 11 |
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|
Major genes of the cAMP, cGMP and calcium signaling pathways |
||||
| Function |
Gene name |
Signal |
Enrichment |
Comments |
|
|
||||
| cAMP |
||||
| Adenylate cyclase |
rutabage |
121 ± 12 |
1.4 ± .2 |
|
| Ac78C |
44 ± 5 |
7.2 ± 1.6 |
||
| Ac13E |
106 ± 4 |
4.1 ± 0.5 |
||
| Protein kinase A |
Pka-C3 |
88 ± 9 |
1.7 ± 0.2 |
Catalytic subunit |
| Pka-R1 |
183 ± 13 |
1.2 ± 0.1 |
Regulatory subunit |
|
| PDE |
dunce |
147 ± 6 |
3.9 ± 0.6 |
cAMP-specific |
| Calcium |
||||
| CamKinase |
Caki |
112 ± 10 |
1.7 ± 0.2 |
|
| Phospholipase C |
Small wing |
46 ± 6 |
1.1 ± 0.2 |
|
| Plc21C |
58 ± 5 |
1.1 ± 0.1 |
||
| Calcium release channels |
Itp-r83A |
11 ± 2 |
1.2 ± 0.2 |
InsP3 receptor |
| Calmodulin |
Calmodulin |
1,019 ± 57 |
0.9 ± 0.06 |
|
| Protein kinase C |
Pkc98E |
217 ± 15 |
1.7 ± 0.2 |
|
| cGMP |
||||
| Guanylate cyclase |
CG14885 |
13 ± 3 |
6 ± 2.5 |
Probably soluble beta subunit |
| Gyc76C |
410 ± 23 |
2.9 ± 0.4 |
Membrane form |
|
| CG4224 |
23 ± 4 |
0.8 ± 0.2 |
Membrane form |
|
| CG9873 |
137 ± 5 |
2.0 ± 0.7 |
Membrane form |
|
| Gycbeta100B |
20 ± 4 |
0.8 ± 0.1 |
Cytoplasmic, beta subunit |
|
| CG5719 |
9 ± 3 |
3.5 ± 1.4 |
Membrane form |
|
| PDE |
CG10231 |
182 ± 4 |
3.7 ± 0.6 |
cGMP-specific, PDE11-like |
| Protein kinase G |
foraging |
91 ± 2 |
0.3 ± 0.01 |
|
| Pkg21D |
448 ± 20 |
15.7 ± 2.3 |
||
| Serine/threonine protein phosphatases |
||||
| Cg17746 |
258 ± 32 |
4.3 ± 0.6 |
PPA-2C like |
|
| puckered |
228 ± 11 |
2.5 ± 0.2 |
Multifunctional |
|
| twins |
209 ± 11 |
2.0 ± 0.1 |
PPA-2A like |
|
| Pp2A-29B |
738 ± 28 |
1.9 ± 0.2 |
PPA-2A like |
|
| Microtubule star |
997 ± 46 |
1.3 ± 0.1 |
PPA-2A like |
|
| Pp1-87B |
318 ± 17 |
1.1 ± 0 |
PPA-1 like |
|
| Pp1alpha-96A |
332 ± 8 |
1.1 ± 0 |
PPA-1 like |
|
| Accessory proteins, associated with anchoring, cellular localization or modulation
of signaling |
||||
| Akap550 |
136 ± 6 |
2 ± 0.3 |
A-kinase anchor protein |
|
| AKAP200 |
414 ± 30 |
0.35 ± 0.02 |
||
| 14-3-3-zeta |
1,789 ± 42 |
2.6 ± 0.2 |
Diacylglycerol-activated PKC inhibitor |
|
| CG32812 |
42 ± 4 |
2.7 ± 0.4 |
Calcineurin |
|
| Rack1 |
6,463 ± 105 |
1.3 ± 0 |
Receptor for activated C-kinase |
|
|
|
||||
|
Wang et al. Genome Biology 2004 5:R69 doi:10.1186/gb-2004-5-9-r69 |
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