Table 11

Major genes of the cAMP, cGMP and calcium signaling pathways

Function

Gene name

Signal

Enrichment

Comments


cAMP

Adenylate cyclase

rutabage

121 ± 12

1.4 ± .2

Ac78C

44 ± 5

7.2 ± 1.6

Ac13E

106 ± 4

4.1 ± 0.5

Protein kinase A

Pka-C3

88 ± 9

1.7 ± 0.2

Catalytic subunit

Pka-R1

183 ± 13

1.2 ± 0.1

Regulatory subunit

PDE

dunce

147 ± 6

3.9 ± 0.6

cAMP-specific

Calcium

CamKinase

Caki

112 ± 10

1.7 ± 0.2

Phospholipase C

Small wing

46 ± 6

1.1 ± 0.2

Plc21C

58 ± 5

1.1 ± 0.1

Calcium release channels

Itp-r83A

11 ± 2

1.2 ± 0.2

InsP3 receptor

Calmodulin

Calmodulin

1,019 ± 57

0.9 ± 0.06

Protein kinase C

Pkc98E

217 ± 15

1.7 ± 0.2

cGMP

Guanylate cyclase

CG14885

13 ± 3

6 ± 2.5

Probably soluble beta subunit

Gyc76C

410 ± 23

2.9 ± 0.4

Membrane form

CG4224

23 ± 4

0.8 ± 0.2

Membrane form

CG9873

137 ± 5

2.0 ± 0.7

Membrane form

Gycbeta100B

20 ± 4

0.8 ± 0.1

Cytoplasmic, beta subunit

CG5719

9 ± 3

3.5 ± 1.4

Membrane form

PDE

CG10231

182 ± 4

3.7 ± 0.6

cGMP-specific, PDE11-like

Protein kinase G

foraging

91 ± 2

0.3 ± 0.01

Pkg21D

448 ± 20

15.7 ± 2.3

Serine/threonine protein phosphatases

Cg17746

258 ± 32

4.3 ± 0.6

PPA-2C like

puckered

228 ± 11

2.5 ± 0.2

Multifunctional

twins

209 ± 11

2.0 ± 0.1

PPA-2A like

Pp2A-29B

738 ± 28

1.9 ± 0.2

PPA-2A like

Microtubule star

997 ± 46

1.3 ± 0.1

PPA-2A like

Pp1-87B

318 ± 17

1.1 ± 0

PPA-1 like

Pp1alpha-96A

332 ± 8

1.1 ± 0

PPA-1 like

Accessory proteins, associated with anchoring, cellular localization or modulation of signaling

Akap550

136 ± 6

2 ± 0.3

A-kinase anchor protein

AKAP200

414 ± 30

0.35 ± 0.02

14-3-3-zeta

1,789 ± 42

2.6 ± 0.2

Diacylglycerol-activated PKC inhibitor

CG32812

42 ± 4

2.7 ± 0.4

Calcineurin

Rack1

6,463 ± 105

1.3 ± 0

Receptor for activated C-kinase


Wang et al. Genome Biology 2004 5:R69   doi:10.1186/gb-2004-5-9-r69

Open Data