Genome Biology

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Computational prediction of human metabolic pathways from the complete human genome

Pedro Romero, Jonathan Wagg, Michelle L Green, Dale Kaiser, Markus Krummenacker and Peter D Karp*

Genome Biology 2004, 6:R2 doi:10.1186/gb-2004-6-1-r2

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Critical assessment of human metabolic pathway databases: a stepping stone for future integration

Miranda D Stobbe, Sander M Houten, Gerbert A Jansen, Antoine HC van Kampen, Perry D Moerland BMC Systems Biology 2011, 5:165 (14 October 2011)

Research article   Open Access Highly Accessed

Structural diversity of biologically interesting datasets: a scaffold analysis approach

Varun Khanna, Shoba Ranganathan Journal of Cheminformatics 2011, 3:30 (8 August 2011)

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A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle

Anthony C Smith, Alan J Robinson BMC Systems Biology 2011, 5:102 (29 June 2011)

Proceedings   Open Access

Network analysis of human protein location

Gaurav Kumar, Shoba Ranganathan BMC Bioinformatics 2010, 11(Suppl 7):S9 (15 October 2010)

Proceedings   Open Access

HPD: an online integrated human pathway database enabling systems biology studies

Sudhir R Chowbina, Xiaogang Wu, Fan Zhang, Peter M Li, Ragini Pandey, Harini N Kasamsetty, Jake Y Chen BMC Bioinformatics 2009, 10(Suppl 11):S5 (8 October 2009)

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MouseCyc: a curated biochemical pathways database for the laboratory mouse

Alexei V Evsikov, Mary E Dolan, Michael P Genrich, Emily Patek, Carol J Bult Genome Biology 2009, 10:R84 (14 August 2009)

MouseCyc is a database of curated metabolic pathways for the laboratory mouse.

Research   Open Access Highly Accessed

The conservation and evolutionary modularity of metabolism

José M Peregrín-Alvarez, Chris Sanford, John Parkinson Genome Biology 2009, 10:R63 (12 June 2009)

A novel evolutionary analysis of metabolic networks across 26 taxa reveals a highly-conserved but flexible core of metabolic enzymes.

Database   Open Access Highly Accessed

LeishCyc: a biochemical pathways database for Leishmania major

Maria A Doyle, James I MacRae, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Vladimir A Likić BMC Systems Biology 2009, 3:57 (5 June 2009)

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Reconstruction of metabolic pathways for the cattle genome

Seongwon Seo, Harris A Lewin BMC Systems Biology 2009, 3:33 (12 March 2009)

Methodology article   Open Access Highly Accessed

Gene Vector Analysis (Geneva): A unified method to detect differentially-regulated gene sets and similar microarray experiments

Stephen W Tanner, Pankaj Agarwal BMC Bioinformatics 2008, 9:348 (22 August 2008)

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Meta-Analysis Approach identifies Candidate Genes and associated Molecular Networks for Type-2 Diabetes Mellitus

Axel Rasche, Hadi Al-Hasani, Ralf Herwig BMC Genomics 2008, 9:310 (30 June 2008)

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Analysis of Aspergillus nidulans metabolism at the genome-scale

Helga David, İlknur Ş Özçelik, Gerald Hofmann, Jens Nielsen BMC Genomics 2008, 9:163 (11 April 2008)

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Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia

Tunahan Çakιr, Selma Alsan, Hale Saybaşιlι, Ata Akιn, Kutlu Ö Ülgen Theoretical Biology and Medical Modelling 2007, 4:48 (10 December 2007)

Research article   Open Access

A survey of orphan enzyme activities

Yannick Pouliot, Peter D Karp BMC Bioinformatics 2007, 8:244 (10 July 2007)

Research   Open Access

e-Science and biological pathway semantics

Joanne S Luciano, Robert D Stevens BMC Bioinformatics 2007, 8(Suppl 3):S3 (9 May 2007)

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Reactome: a knowledge base of biologic pathways and processes

Imre Vastrik, Peter D'Eustachio, Esther Schmidt, Geeta Joshi-Tope, Gopal Gopinath, David Croft, Bernard de Bono, Marc Gillespie, Bijay Jassal, Suzanna Lewis, Lisa Matthews, Guanming Wu, Ewan Birney, Lincoln Stein Genome Biology 2007, 8:R39 (16 March 2007)

Reactome, an online curated resource for human pathway data, can be used to infer equivalent reactions in non-human species and as a tool to aid in the interpretation of microarrays and other high-throughput data sets.

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The Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data

Terry F Hayamizu, Mary Mangan, John P Corradi, James A Kadin, Martin Ringwald Genome Biology 2005, 6:R29 (15 February 2005)

This article is part of a collection on Ontologies

The Adult Mouse Anatomical Dictionary was developed to provide an ontology for standardized nomenclature for anatomical terms in the postnatal mouse. The ontology will be used to annotate and integrate different types of data pertinent to anatomy.