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Open Access Method

The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information

Cynthia L Smith1, Carroll-Ann W Goldsmith12 and Janan T Eppig1*

Author Affiliations

1 The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA

2 Massachusetts College of Pharmacy and Health Sciences, School of Pharmacy Manchester, 1260 Elm Street, Manchester, NH 03101, USA

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Genome Biology 2004, 6:R7  doi:10.1186/gb-2004-6-1-r7

Published: 15 December 2004

Abstract

The Mammalian Phenotype (MP) Ontology enables robust annotation of mammalian phenotypes in the context of mutations, quantitative trait loci and strains that are used as models of human biology and disease. The MP Ontology supports different levels and richness of phenotypic knowledge and flexible annotations to individual genotypes. It continues to develop dynamically via collaborative input from research groups, mutagenesis consortia, and biological domain experts. The MP Ontology is currently used by the Mouse Genome Database and Rat Genome Database to represent phenotypic data.