Review
Global approaches to understanding ubiquitination
1 Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA
2 Department of Physiology and Biophysics, University of California, Irvine, CA 92697-1700, USA
3 Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-1700, USA
Genome Biology 2005, 6:233 doi:10.1186/gb-2005-6-10-233
Published: 29 September 2005Abstract
Ubiquitination - the linkage of one or more molecules of the protein ubiquitin to another protein - regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.
