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Highly Accessed Review

Global approaches to understanding ubiquitination

Peter Kaiser1* and Lan Huang23

Author affiliations

1 Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA

2 Department of Physiology and Biophysics, University of California, Irvine, CA 92697-1700, USA

3 Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-1700, USA

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Citation and License

Genome Biology 2005, 6:233  doi:10.1186/gb-2005-6-10-233

Published: 29 September 2005

Abstract

Ubiquitination - the linkage of one or more molecules of the protein ubiquitin to another protein - regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.