Table 3 |
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List of genes potentially specifically involved in neoplastic progression in MMTV-Wnt-1 transgenic mice |
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|
Expression ratio |
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|
|
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|
Image ID |
Gene name |
Symbol |
WntH/V |
WntT/WntH |
WntT/NeuT |
|
|
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|
474107 |
Tumor necrosis factor receptor superfamily, member 19 |
Tnfrsf19 |
2.56 |
3.48 |
6.23 |
|
406897 |
Retinol binding protein 1, cellular |
Rbp1 |
2.93 |
3.02 |
1.96 |
|
572428 |
Cell cycle cyclin D1 Mm.35804 Cyclin D1 |
Ccnd1 |
= |
5.53 |
1.97 |
|
536306 |
Hormone/GF growth/diff 1 Mm.22621 Procollagen type I α1 |
Col1a1 |
= |
3.04 |
3.27 |
|
536526 |
ESTs |
= |
8.8 |
5.95 |
|
|
329780 |
Cadherin 3 |
Cdh3 |
= |
3.74 |
3.96 |
|
427360 |
Mus musculus, clone IMAGE:3590270, mRNA, partial cds |
LOC192176 |
= |
3.5 |
2.44 |
|
638805 |
Expressed sequence AI504637 |
= |
3.3 |
2.27 |
|
|
355990 |
Chondroitin sulfate proteoglycan 2 |
Cspg2 |
= |
3.62 |
5.05 |
|
574500 |
ESTs |
= |
4.13 |
1.65 |
|
|
476431 |
Nerve growth factor receptor |
Ngfr |
= |
3.61 |
6.34 |
|
680894 |
Glial cell line derived neurotrophic factor family receptor α1 |
Gfra1 |
= |
4.74 |
4.05 |
|
482943 |
Odd-skipped related 1 (Drosophila) |
Osr1 |
= |
4.1 |
3.65 |
|
695687 |
Calponin 2 |
Cnn2 |
= |
3.49 |
2.54 |
|
335572 |
Dihydropyrimidinase-like 3 |
= |
3.27 |
7.61 |
|
|
621246 |
Interferon concensus sequence binding protein |
Icsbp |
= |
3.38 |
4.91 |
|
482170 |
Four jointed box 1 (Drosophila) |
Fjx1 |
= |
4.13 |
3.78 |
|
468019 |
IL-17b |
Il17b |
= |
4.27 |
5.37 |
|
373716 |
Tumor-associated calcium signal transducer 2 |
Tacstd2 |
= |
4.16 |
3.69 |
|
479405 |
ESTs |
= |
3.01 |
4.95 |
|
|
722262 |
Wingless-related MMTV integration site 5A |
Wnt5a |
= |
4.44 |
9.23 |
|
719592 |
GATA binding protein 2 |
Gata2 |
= |
6.06 |
10.54 |
|
1247541 |
Apolipoprotein D |
Apod |
= |
4.67 |
3.86 |
|
331186 |
Caveolin, caveolae protein, 22 kDa |
Cav1 |
0.31 |
0.29 |
3.67 |
|
596968 |
Caveolin, caveolae protein, 22 kDa |
Cav1 |
0.3 |
0.31 |
3.05 |
|
948509 |
Caveolin, caveolae protein, 22 kDa |
Cav1 |
0.52 |
0.18 |
3 |
|
386555 |
CD36 antigen |
Cd36 |
0.21 |
0.06 |
0.08 |
|
832585 |
ESTs |
0.21 |
0.06 |
0.21 |
|
|
620819 |
transcription elongation factor A (SII) 1 |
AI158848 |
0.24 |
0.07 |
0.25 |
|
831701 |
ESTs |
0.2 |
0.09 |
0.25 |
|
|
775253 |
ESTs |
0.16 |
0.07 |
0.22 |
|
|
334182 |
Unknown |
0.24 |
0.06 |
0.21 |
|
|
493675 |
Riken cDNA 2700018N07 gene |
Scd1 |
0.18 |
0.1 |
0.21 |
|
571367 |
Riken cDNA 2410012F02 gene |
0.24 |
0.11 |
0.27 |
|
|
463388 |
Epoxide hydrolase 2, cytoplasmic |
Ephx2 |
0.3 |
0.11 |
0.41 |
|
374030 |
EST |
0.25 |
0.11 |
0.33 |
|
|
1067881 |
Fc receptor, IgG, low affinity III |
Fcgr3 |
0.36 |
0.16 |
0.26 |
|
474184 |
Expressed sequence AW554339 |
0.3 |
0.15 |
0.33 |
|
|
579349 |
Expressed sequence AI593221 |
2410127E18Rik |
0.29 |
0.18 |
0.23 |
|
874232 |
Riken cDNA 1110025G12 gene |
1110025G12Rik |
0.33 |
0.19 |
0.56 |
|
891453 |
Expressed sequence AI315208 |
AI315208 |
= |
0.2 |
0.16 |
|
1399595 |
Riken cDNA 2810422B09 gene |
1810061M12Rik |
0.3 |
0.18 |
0.4 |
|
737745 |
ESTs |
0.34 |
0.17 |
0.37 |
|
|
876063 |
BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 |
Bnip3 |
0.38 |
0.27 |
0.62 |
|
850642 |
Epoxide hydrolase 2, cytoplasmic |
Ephx2 |
0.18 |
0.22 |
0.44 |
|
1248105 |
Expressed sequence AI595343 |
AI595343 |
0.42 |
0.21 |
0.37 |
|
330661 |
Mus musculus golli-interacting protein mRNA, complete cds |
Nif3 |
0.66 |
0.21 |
0.22 |
|
1349720 |
Apoptosis NIP3, Bcl-2-binding protein homolog (Nip3) mRNA |
Bnip3 |
0.37 |
0.29 |
0.52 |
|
1067414 |
Expressed sequence AI413399 |
1110001E17Rik |
= |
0.24 |
0.52 |
|
832584 |
ESTs, Weakly similar to STHM MOUSE STATHMIN [M. musculus] |
0.31 |
0.21 |
0.46 |
|
|
876369 |
Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) |
Als2 |
0.41 |
0.29 |
0.39 |
|
764542 |
ESTs, Weakly similar to GPRY_mouse probable G protein-coupled receptor GPR34 [M. musculus] |
Gpr43 |
0.49 |
0.24 |
0.43 |
|
1248075 |
Transcription factor 1 |
Tcf1 |
0.29 |
0.31 |
0.36 |
|
949592 |
ESTs, Moderately similar to hypothetical protein [H. sapiens] |
= |
0.32 |
0.22 |
|
|
1195295 |
Actinin α3 |
Actn3 |
= |
0.29 |
0.43 |
|
820307 |
A kinase (PRKA) anchor protein (gravin) 12 |
Akap12 |
= |
0.31 |
0.08 |
|
864409 |
Riken cDNA 1200013I08 gene |
1200013I08Rik |
0.47 |
0.33 |
0.39 |
|
947659 |
Riken cDNA 2310016E22 gene |
2310016E22Rik |
= |
0.33 |
0.37 |
|
1396547 |
Myosin binding protein H |
= |
0.25 |
0.45 |
|
|
|
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|
This list displays genes that are differentially expressed between mammary tumors (WntT) and hyperplastic mammary gland (WntH) from MMTV-Wnt-1 transgenic mice, and that are also differentially expressed between WntT and mammary tumors from MMTV-Neu transgenic mice (NeuT). Genes are sorted according to the average ratio of WntT versus WntH. A numeric ratio is displayed if the gene expression meets the criteria (statistical significance and fold cutoff) described in Table 2; otherwise, it is marked as '=', indicating that there is no significant difference between the two sets of samples in comparison. EST, expressed sequence tag; MMTV, mouse mammary tumor virus. |
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|
Huang et al. Genome Biology 2005 6:R84 doi:10.1186/gb-2005-6-10-r84 |
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