Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Open Access Highly Accessed Method

Searching for differentially expressed gene combinations

Marcel Dettling1*, Edward Gabrielson12 and Giovanni Parmigiani123

Author Affiliations

1 Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA

2 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA

3 Department of Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA

For all author emails, please log on.

Genome Biology 2005, 6:R88  doi:10.1186/gb-2005-6-10-r88

Published: 19 September 2005

Abstract

We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.