Method
Searching for differentially expressed gene combinations
1 Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
2 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
3 Department of Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Genome Biology 2005, 6:R88 doi:10.1186/gb-2005-6-10-r88
Published: 19 September 2005Abstract
We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.
