Table 3 |
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|
Potential domain interactions between Ran homologs and Ran-binding proteins |
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|
Ran homolog domain |
Ran-binding protein domain |
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|
|
|
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|
Pfam ID |
Pfam accession |
Pfam ID |
Pfam accession |
θ |
E |
|
|
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|
Pfam-B_1470 |
PB001470 |
Ran_BP1 |
PF00638 |
0.31 |
3.6 |
|
Pfam-B_1470 |
PB001470 |
Pfam-B_102314 |
PB102314 |
0.42 |
0.46 |
|
Pfam-B_1470 |
PB001470 |
Pfam-B_5293 |
PB005293 |
0.14 |
0.19 |
|
Pfam-B_1470 |
PB001470 |
Pfam-B_93946 |
PB093946 |
0.55 |
0.19 |
|
Pfam-B_1470 |
PB001470 |
Pfam-B_87101 |
PB087101 |
0.20 |
0.19 |
|
Pfam-B_1470 |
PB001470 |
Pfam-B_73892 |
PB073892 |
0.35 |
0.075 |
|
Ras |
PF00071 |
Pfam-B_102314 |
PB102314 |
0.039 |
0.018 |
|
Ras |
PF00071 |
Pfam-B_93946 |
PB093946 |
0.092 |
0.014 |
|
Ras |
PF00071 |
Ran_BP1 |
PF00638 |
0.008 |
0.011 |
|
Ras |
PF00071 |
Pfam-B_87101 |
PB087101 |
0.013 |
0.009 |
|
Ras |
PF00071 |
Pfam-B_5293 |
PB005293 |
0.008 |
0.008 |
|
Pfam-B_1470 |
PB001470 |
zf-RanBP |
PF00641 |
0.053 |
0.008 |
|
Ras |
PF00071 |
Pfam-B_73892 |
PB073892 |
0.029 |
0.004 |
|
Ras |
PF00071 |
zf-RanBP |
PF00641 |
0.004 |
0.000 |
|
|
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|
Several domain interactions are possible in the interactions of yeast and worm Ran signal-transducing proteins with some Ran-binding proteins. Of these possible domain interactions, DPEA predicts the interaction (E = 3.6) of a Pfam-B domain [Pfam:PB001470] found at the C-termini of Ran homologs but not in other Ras family members [Pfam:PF00071] with Ran-binding domains [Pfam:PF00638, Ran_BP1]. Structural [43] and biochemical [44] studies confirm this interaction. We conclude that DPEA identified, from among several possibilities, an important domain interaction for the interaction of Ran homologs with a subset of Ran-binding proteins. |
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|
Riley et al. Genome Biology 2005 6:R89 doi:10.1186/gb-2005-6-10-r89 |
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