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Highly Accessed Review

Large-scale approaches for glycobiology

Christopher T Campbell and Kevin J Yarema*

Author Affiliations

Department of Biomedical Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA

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Genome Biology 2005, 6:236  doi:10.1186/gb-2005-6-11-236

Published: 3 November 2005

Abstract

Glycosylation, the attachment of carbohydrates to proteins and lipids, influences many biological processes. Despite detailed characterization of the cellular components that carry out glycosylation, a complete picture of a cell's glycoconjugates remains elusive because of the challenges inherent in characterizing complex carbohydrates. This article reviews large-scale techniques for accelerating progress in glycobiology.