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Virus-host interactions: new insights from the small RNA world

Edward P Browne*, Junjie Li, Mark Chong and Dan R Littman*

Author Affiliations

Molecular Pathogenesis Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA

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Genome Biology 2005, 6:238  doi:10.1186/gb-2005-6-11-238

Published: 31 October 2005

Abstract

RNA silencing has a known role in the antiviral responses of plants and insects. Recent evidence, including the finding that the Tat protein of human immunodeficiency virus (HIV) can suppress the host's RNA-silencing pathway and may thus counteract host antiviral RNAs, suggests that RNA-silencing pathways could also have key roles in mammalian virus-host interactions.