Research
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage
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* Corresponding author: Jonathan C Howard j.howard@uni-koeln.de
1 Institute for Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany
2 Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA
3 Informatics & Systems Groups, Sanger Centre, The Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK
4 Department of Structural Biology, Stanford University Medical School, Stanford, CA 94305, USA
5 Institute for Microbiology and Immunology, University of Cologne Medical School, 50935 Cologne, Germany
Genome Biology 2005, 6:R92 doi:10.1186/gb-2005-6-11-r92
Published: 31 October 2005Additional files
Additional data file 1:
A list of all IRG gene family members described in this paper (gives names, synonyms, accession numbers and further information for each IRG gene)
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Additional data file 2:
Nucleotide and amino acid identities based on G-domain of mouse Irg family (gives percentage of identity on both protein and nucleotide level within the mouse IRG family)
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Additional data file 3:
ISRE and GAS elements of mouse IRG family genes (contains the positions and exact sequences of all ISRE and GAS elements found in putative promoters of mouse IRG genes)
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Additional data file 4:
Inducibility of Dog p47 (IRG) GTPases (shows interferon inducibility of members of the p47 (IRG) GTPases present in the dog)
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Additional data file 5:
Genomic organization of Danio rerio p47 (IRG) GTPases (illustrates the genomic organization of all p47 (IRG) GTPases found in zebrafish to date)
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Additional data file 6:
Protein similarity matrix of Irgc and Irgq (contains comparison between the mouse p47 GTPase Irgc and the long coding exon of the closely linked quasi-GTPase Irgq (FKSG27)
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Additional data file 7:
Divergent nucleotide-binding motifs in quasi-GTPases (compares the nucleotide binding motifs of quasi-GTPases to those of the classical mouse p47 GTPases)
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Additional data file 8:
A list of the primers used (contains the sequences of all primers used in this study)
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Additional data file 9:
Nucleotide sequences of all IRG family members
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Additional data file 10:
Protein sequences of all IRG family members
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