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Open Access Research

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

Cemalettin Bekpen1, Julia P Hunn1, Christoph Rohde1, Iana Parvanova1, Libby Guethlein14, Diane M Dunn2, Eva Glowalla15, Maria Leptin13 and Jonathan C Howard1*

Author Affiliations

1 Institute for Genetics, University of Cologne, Z├╝lpicher Strasse 47, 50674 Cologne, Germany

2 Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA

3 Informatics & Systems Groups, Sanger Centre, The Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA UK

4 Department of Structural Biology, Stanford University Medical School, Stanford, CA 94305, USA

5 Institute for Microbiology and Immunology, University of Cologne Medical School, 50935 Cologne, Germany

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Genome Biology 2005, 6:R92  doi:10.1186/gb-2005-6-11-r92

Published: 31 October 2005

Additional files

Additional data file 1:

A list of all IRG gene family members described in this paper (gives names, synonyms, accession numbers and further information for each IRG gene)

Format: PDF Size: 180KB Download file

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Open Data

Additional data file 2:

Nucleotide and amino acid identities based on G-domain of mouse Irg family (gives percentage of identity on both protein and nucleotide level within the mouse IRG family)

Format: PDF Size: 59KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 3:

ISRE and GAS elements of mouse IRG family genes (contains the positions and exact sequences of all ISRE and GAS elements found in putative promoters of mouse IRG genes)

Format: PDF Size: 105KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 4:

Inducibility of Dog p47 (IRG) GTPases (shows interferon inducibility of members of the p47 (IRG) GTPases present in the dog)

Format: PDF Size: 50KB Download file

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Open Data

Additional data file 5:

Genomic organization of Danio rerio p47 (IRG) GTPases (illustrates the genomic organization of all p47 (IRG) GTPases found in zebrafish to date)

Format: PDF Size: 41KB Download file

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Open Data

Additional data file 6:

Protein similarity matrix of Irgc and Irgq (contains comparison between the mouse p47 GTPase Irgc and the long coding exon of the closely linked quasi-GTPase Irgq (FKSG27)

Format: PDF Size: 68KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 7:

Divergent nucleotide-binding motifs in quasi-GTPases (compares the nucleotide binding motifs of quasi-GTPases to those of the classical mouse p47 GTPases)

Format: PDF Size: 77KB Download file

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Open Data

Additional data file 8:

A list of the primers used (contains the sequences of all primers used in this study)

Format: PDF Size: 95KB Download file

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Open Data

Additional data file 9:

Nucleotide sequences of all IRG family members

Format: DOC Size: 96KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional data file 10:

Protein sequences of all IRG family members

Format: DOC Size: 57KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data