Extended phylogeny of the G domains of IRG and related proteins. The phylogeny relates all of the IRG sequences described in this report and reveals the distinct clades on which the nomenclatural fine structure is based. All except the mouse sequences are labeled with the species of origin. Dog IRG sequences are found in the B, C, D and M clades, and human sequences only in clades C and M. The mouse and human quasi-IRG proteins, IRGQ (FKSG27), could not be included in the phylogeny because they are so deviant in the G-domain (see Figure 6 and Additional data file 6).
Bekpen et al. Genome Biology 2005 6:R92 doi:10.1186/gb-2005-6-11-r92