Table 2 |
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|
Survey of candidate genes previously implicated in Drosophila defense and immunity |
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|
Functional classification of proteins or genes |
Differentially expressed candidate gene |
Cluster number |
|
|
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|
Hemocyte proliferation and differentiationa |
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|
JAK/STAT pathway |
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|
Ligands |
- |
|
|
Receptors |
dome (CG14226), CG14225 |
2 |
|
JAK |
hop (CG1594) |
2 |
|
STAT |
- |
|
|
Possible effector molecules |
TepI (CG18096), TepII (CG7052), TepIV (CG10363) |
12 |
|
TotB (CG5609) |
8 |
|
|
Toll pathway (in lymph glands) |
||
|
Ligands |
- |
|
|
Regulators of pathway |
nec (CG1857) |
2 |
|
Receptors |
Tl (CG5490) |
3 |
|
Intracellular signaling elements |
- |
|
|
NF-κB transcription factor |
Relish (CG11992) |
4 |
|
Ras/Raf/MAPK pathway |
- |
|
|
Notch pathway |
- |
|
|
VEGF receptor pathway |
- |
|
|
GATA factor homologs (e.g. srp) |
- |
|
|
RUNX/AML1-like proteins (lz) |
- |
|
|
Cellular defense, in particular encapsulationb |
||
|
Recognition/surface binding factors |
||
|
Extracellular matrix (ECM) proteins (e.g. laminin, collagen IV, fibronectin) |
dome (CG14226) |
2 |
|
prc (CG5700) |
14 |
|
|
Hml (CG7002) |
10 |
|
|
CG6788/CG32496 |
11 |
|
|
Integrins |
αPS4 (CG16827) |
11 |
|
Immunoglobulin superfamily members |
Pxn (CG12002) |
6 |
|
CG8100 |
10 |
|
|
CG14225 |
13 |
|
|
Scavenger receptors (CD36-like) |
CG12789 |
4 |
|
CG2736 |
10 |
|
|
Tequila (CG4821) |
12 |
|
|
Possible pattern recognition receptors |
lectin-24A (CG3410) |
12 |
|
G-protein type receptors |
mthl2 (CG17795) |
11 |
|
Surface helper molecules |
||
|
Vinculin, talin, paxillins |
- |
|
|
Surface-associated signaling molecules |
||
|
Integrin-linked focal adhesion kinases (FAKs) |
- |
|
|
Integral membrane proteins |
rost (CG9552) |
4 |
|
Tsp42Ek (CG12841) |
9 |
|
|
Intracellular signaling pathway factors |
||
|
Phosphotidylinositol 3-kinase (PI3K) |
- |
|
|
GTP-binding proteins (Ras/Rho family members) |
- |
|
|
Protein kinase C (PKCs) or PKC regulators |
CG5958 (PKC transporter) |
10 |
|
Protein tyrosine phosphatase (PTPs) |
dome (CG14226) |
2 |
|
Serine/threonine kinases |
- |
|
|
Scaffolding proteins (RACK) |
- |
|
|
Cytoskeletal proteins (actins, tubulins, for example) |
αTub85E (CG9476), αTub84D (CG2512), αTub84E (CG1913), βTub60D (CG3401) |
11 |
|
Eicosinoid pathway elements |
- |
|
|
Effector molecules |
||
|
NO pathway factors |
- |
|
|
PPO pathway factors |
Dox-A3 (CG2952), CG11313, |
11 |
|
G8193, Bc (CG5779), |
9 |
|
|
Fmo-2 (CG3174) |
15 |
|
|
Porferins or related molecules |
- |
|
|
Tumor necrosis factor (TNFs) |
CG13559 |
2 |
|
Humoral defenseb |
||
|
Humoral pattern-recognition receptors |
PGRP-SB1 (CG9681) |
1 |
|
lectin-24A (CG3410) |
12 |
|
|
Hml (CG7002) |
10 |
|
|
Serine proteases |
CG3066 |
2 |
|
CG30414, CG30086, CG30090, Tequila (CG4821), CG16705, CG31780 / BG:DS07108.1 (CG18477), CG6639, CG3117, CG31827/BG:DS07108.5 (CG18478), CG18563, CG4793, CG4259 |
12 |
|
|
CG11313 |
11 |
|
|
CG16713 |
4 |
|
|
Serpins and other protease inhibitors |
nec |
2 |
|
CG6687, CG16712, CG16705, TepI (CG18096), TepII (CG7052), TepIV (CG10363) |
12 |
|
|
BcDNA:SD04019 (CG17278) |
14 |
|
|
CG16704 |
1 |
|
|
Known ligand-like molecules (e.g. spz) |
- |
|
|
Surface receptors |
||
|
Toll and associated family members |
TI (CG5490) |
3 |
|
Toll or imd pathway (in fatbody) |
||
|
Intracellular signalling elements (e.g., tube, Pelle, DTRAF, DECSIT) |
- |
|
|
NF-κB transcription factor |
Rel (CG11992) |
4 |
|
Effector molecules or antimicrobial peptides |
AttA (CG10146), AttB (CG18372) |
1 |
|
Mtk (CG8175), IM1 (CG18108), IM2 (CG18106), CG13422, CG15066 |
2 |
|
|
IM4 (CG15231), CG18279, CG16844 |
14 |
|
|
Related apoptotic regulators |
||
|
Dredd |
- |
|
|
Ubiquitins |
- |
|
|
PPO and associated pathway molecules |
Dox-A3 (CG2952) |
11 |
|
Melanin and free-radical intermediates |
Fmo-2 (CG3174) |
15 |
|
|
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|
The table lists the different functional classes of genes and protein surveyed, any genes in these classes that were differentially expressed, and the cluster the gene was assigned to. Note that some genes with multiple annotations can appear in more than one category. aBased on [17,66,90,91]; bbased on [11,92] (MR Strand, personal communication). |
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|
Wertheim et al. Genome Biology 2005 6:R94 doi:10.1186/gb-2005-6-11-r94 |
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