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Splicing regulators: targets and drugs

Gene Wei-Ming Yeo

Author Affiliations

Crick-Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

Genome Biology 2005, 6:240  doi:10.1186/gb-2005-6-12-240

Published: 1 December 2005

Abstract

Silencing of splicing regulators by RNA interference, combined with splicing-specific microarrays, has revealed a complex network of distinct alternative splicing events in Drosophila, while a high-throughput screen of more than 6,000 compounds has identified drugs that interfere specifically and directly with one class of splicing regulators in human cells.