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Predicting the sites of metastases

Brian Z Ring and Douglas T Ross

Author Affiliations

Applied Genomics Inc., 525 Del Rey Avenue, Sunnyvale, CA 94085, USA

Genome Biology 2005, 6:241  doi:10.1186/gb-2005-6-12-241

Published: 2 December 2005

Abstract

Transplantation of human breast cancer cells into immunodeficient mice together with gene-expression microarray studies has recently identified genes implicated in the tissue tropism of breast-cancer metastasis. Such signatures of site-specific metastatic capabilities might allow the targeting of therapy to likely sites of metastasis.